On detection of periodicity in C-reactive protein (CRP) levels

Dorraki, Mohsen; Fouladzadeh, Anahita; Salamon, Stephen J.; Allison, Andrew; Coventry, Brendon J.; Abbott, Derek

doi:10.1038/s41598-018-30469-8

Cited by 19 publications

(19 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In summary, the circaseptan (7-day ± 1-day) periodicity pattern described, in some cases accompanied by other infradian cycles, such as a hemicircaseptan cycle, is robust in large and reliably reporting countries representing Europe (Italy; Germany, Sweden, United Kingdom), Asia (Japan, South Korea), and North (the United States) and South (Brazil) America, as well as in the whole world. Understanding the relationship between variables associated with the observed periodicities might help in health care improvements, better forecasting of the coronavirus infection, and stock market expectations about economic growth and might help provide a clue for the most suitable times at which expected COVID-19 therapies should be administered ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Oscillatory Dynamics in Infectivity and Death Rates of COVID-19

Pavlı́ček

Řehák

2020

mSystems

View full text Add to dashboard Cite

The analysis of systematically collected data for coronavirus disease 2019 (COVID-19) infectivity and death rates has revealed, in many countries around the world, a typical oscillatory pattern with a 7-day (circaseptan) period. Additionally, in some countries, 3.5-day (hemicircaseptan) and 14-day periodicities have also been observed. Interestingly, the 7-day infectivity and death rate oscillations are almost in phase, showing local maxima on Thursdays/Fridays and local minima on Sundays/Mondays. These observations are in stark contrast to a known pattern correlating the death rate with the reduced medical staff in hospitals on the weekends. While we cannot exclude the possibility that a significant portion of the observed oscillations is associated with the reporting of the individual cases, other reasons might contribute at least partly to these data. One possible hypothesis addressing these observations is that they reflect gradually increasing stress with the progressing week, which can trigger the higher death rates on Thursdays/Fridays. Moreover, assuming the weekends provide the likely time for new infections, the maximum number of new cases might fall, again, on Thursdays/Fridays. These observations deserve further study to provide a better understanding of COVID-19 dynamics. IMPORTANCE The infectivity and death rates for COVID-19 have been observed in many countries around the world as well as in the collective data of the whole world. These oscillations show distinct circaseptan periodicity, which could be associated with numerous biological reasons as well as with improper reporting of the data collected. Since very different results are observed in different countries and even continents, such as Sweden (very significant oscillations) or India (almost no oscillations), these data provide a very important message about different conditions under which the disease is spread or is reported, which, in turn, could serve as guidance tools in future epidemics. It is necessary that follow-up studies track the observed differences and fully reliably address their origins.

show abstract

Section: Discussionmentioning

confidence: 99%

Oscillatory Dynamics in Infectivity and Death Rates of COVID-19

Pavlı́ček

Řehák

2020

mSystems

View full text Add to dashboard Cite

show abstract

“…The application of immune therapies or cytotoxic chemotherapies to the oscillating and fluctuating immune system occurring in the individual patient presents a significant problem if the action of the specific agent depends on precisely when the agent is administered with reference to the phase of activation or inhibition of the immune system at the time. Recent work has been unable to accurately define the periodicity of the immune oscillation in cancer patients despite initial work using less robust mathematics appearing to show this [139][140][141][142] . Advanced mathematics and periodicity models have been incapable of verifying regular, consistent, clear, regular immune cycles, principally due to infrequent inflammatory marker serial sampling and confounding noise-to-signal issues, but machine (deep) learning may offer alternative methods.…”

Section: Anti-cancer Agents and Immune Responsesmentioning

confidence: 99%

The Immune System and Responses to Cancer: Coordinated Evolution

Coventry¹,

Ashdown²,

Henneberg³

2020

F1000Res

Self Cite

View full text Add to dashboard Cite

This review explores the incessant evolutionary interaction and co-development between immune system evolution and somatic evolution, to put it into context with the short, over 60-year, detailed human study of this extraordinary protective system. Over millions of years, the evolutionary development of the immune system in most species has been continuously shaped by environmental interactions between microbes, and aberrant somatic cells, including malignant cells. Not only has evolution occurred in somatic cells to adapt to environmental pressures for survival purposes, but the immune system and its function has been successively shaped by those same evolving somatic cells and microorganisms through continuous adaptive symbiotic processes of progressive simultaneous immunological and somatic change to provide what we observe today. Indeed, the immune system as an environmental influence has also shaped somatic and microbial evolution. Although the immune system is tuned to primarily controlling microbiological challenges for combatting infection, it can also remove damaged and aberrant cells, including cancer cells to induce long-term cures. Our knowledge of how this occurs is just emerging. Here we consider the connections between immunity, infection and cancer, by searching back in time hundreds of millions of years to when multi-cellular organisms first began. We are gradually appreciating that the immune system has evolved into a truly brilliant and efficient protective mechanism, the importance of which we are just beginning to now comprehend. Understanding these aspects will likely lead to more effective cancer and other therapies.

show abstract

“…Besides, the association between prognosis and CRP levels in patients with cancer is currently well established. In particular, CRP is extensively reported in oncology as a reliable biomarker for survival, cancer risks, and tumor recurrence, impacting on many critical decisions in treatment [20]. Moreover, recent clinical and epidemiological studies have demonstrated the association between inflammation and cardiovascular diseases [21].…”

Section: Introductionmentioning

confidence: 99%

Selective single-molecule analytical detection of C-reactive protein in saliva with an organic transistor

et al. 2019

View full text Add to dashboard Cite

In the last decade, saliva has been suggested as non-invasive diagnostic fluid, suitable for clinical use alternatively to blood serum and plasma. However, the clinical applicability of saliva has been hampered so far by the inadequate sensitivity of current methods to detect the lower salivary concentrations of many biomarkers monitored in blood products. Herein, a label-free biosensor based on electrolyte-gated organic thin-film transistor (EGOTFT) has been developed for the detection at the physical limit of C-reactive protein (CRP) in human saliva. CRP is a key relevant biomarker for inflammatory processes and is routinely monitored for many clinical purposes. Herein, an electrolyte-gated thin-film transistor (EGOTFT) has been proposed as a transducer of the biorecognition event taking place at the gate electrode, functionalized with a self-assembled monolayer (SAM) of highly densely packed capturing anti-CRP proteins. Thanks to the SAM, the biosensing platform herein proposed is endowed with ultra-high sensitivity, along with an extremely high selectivity, assessed by measuring the dose curves of CRP interacting with a bovine serum albumin-functionalized gate. Moreover, the biosensing platform is compatible with low-cost fabrication techniques and applicable to the ultra-sensitive detection of a plethora of clinically relevant biomarkers. Therefore, the EGOTFT device herein proposed, being able to operate in physiologically relevant fluids such as saliva, will set the ground to a major revolution in biosensing applications for early clinical detection.

show abstract

On detection of periodicity in C-reactive protein (CRP) levels

Cited by 19 publications

References 44 publications

Oscillatory Dynamics in Infectivity and Death Rates of COVID-19

Oscillatory Dynamics in Infectivity and Death Rates of COVID-19

The Immune System and Responses to Cancer: Coordinated Evolution

Selective single-molecule analytical detection of C-reactive protein in saliva with an organic transistor

Contact Info

Product

Resources

About