High Energy Physics (HEP) experiments have unique requirements for data communication. High data speeds, combined with extreme restrictions on materials allowed, leads to custom transmission lines. This paper will present transmission line design theory, simulation and testing methods. Transmission line designs options like flexes and rigid PCBs as well as cables will be studied. Finite Element Analysis (FEA) software packages simulate energy dissipation and quality of transmitted signals. The characterisation techniques of time-domain reflectometry and frequency-domain measurements are discussed and compared. Bit-error-rate testing is presented and its limitations for design discussed. Methods to improve quality, like three different types of equalization are described.