On distribution of different fecapentaenes, the fecal mutagens, in the human population

Baptista, José; Bruce, W. R.; Gupta, Indranil; Křepinský, Jiří J.; Tassell, Roger L. Van; Wilkins, Tracy D.

doi:10.1016/0304-3835(84)90166-6

Cited by 34 publications

(16 citation statements)

References 5 publications

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“…Examples observed in vitro and in vivo are: hydrolysis of rutin to quercetin (a mutagenic aromatic amine), hydrolysis of cycasin to methylazoxymethanol (70), and hydrolysis of glucuronide-conjugated polycyclic hydrocarbons to their unconjugated, mutagenic forms (71). Fecapentaenes, potent mutagens synthesized by Bacteroides species, are also found in relatively high concentrations in human feces, although their relationship to cancer is unproven (72)(73)(74). Furthermore, bacteria ferment polysaccharides and glycoproteins to volatile fatty acids.…”

Section: Environmental Health Perspectivesmentioning

confidence: 99%

Bacterial infection as a cause of cancer.

Parsonnet

1995

Environ Health Perspect

161

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Bacterial infections traditionally have not been considered major causes of cancer. Recently, however, bacteria have been linked to cancer by two mechanisms: induction of chronic inflammation and production of carcinogenic bacterial metabolites. The most specific example of the inflammatory mechanism of carcinogenesis is Helicobacter pylori infection. H. pylori has been epidemiologically linked to adenocarcinoma of the distal stomach by its propensity to cause lifelong inflammation. This inflammation is in turn thought to cause cancer by inducing cell proliferation and production of mutagenic free radicals and N-nitroso compounds. H. pylori is the first bacterium to be termed a definite cause of cancer in humans by the International Agency for Research on Cancer. Mutagenic bacterial metabolites are also suspected to increase risk for cancer. This model is best exemplified in colon cancer. Bile salt metabolites increase colonic cell proliferation. Exogenous compounds such as rutin may be metabolized into mutagens by resident colonic flora. Moreover, Bacteroides species can produce fecapentaenes, potent in vitro mutagens, in relatively high concentrations. In vivo data on human carcinogenesis by bacterial metabolites, however, are inconsistent. Local bacterial infections may also predispose to nonnodal lymphomas, although the mechanisms for this are unknown. Gastric lymphomas and immunoproliferative small intestinal disease have been most strongly linked to underlying bacterial infection. Because bacterial infections can be cured with antibiotics, identification of bacterial causes of malignancy could have important implications for cancer prevention. -Environ Health Perspect 1 03(Suppl 8): 263-268 (1995)

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Section: Environmental Health Perspectivesmentioning

confidence: 99%

Bacterial infection as a cause of cancer.

Parsonnet

1995

Environ Health Perspect

161

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“…An additional area of interest pertains to a group of suspect carcinogens, the fecapentaenes that are formed by the microbial flora of the large intestine of the human (Gupta et af. 1983;Baptista et al 1984). The fecapentaenes are highly mutagenic in the Ames test and also produce a wide variety of other genotoxic reactions.…”

Section: Inhibition Of Carcinogenesis By Minor Anutrient Constituentsmentioning

confidence: 99%

Inhibition of Carcinogenesis by minor Anutrient Constituents of the Diet

1990

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“…Recently, fecapentaenes, which show mutagenicity towards Salmonella typhimurium TA 100 without metabolic activation, were isolated from human feces (5,6). The fecapentaenes are products of intestinal Bacteriodes, and investigation of the human populations gave no relationship between the fecal occurrence of these compounds and colon cancer (7). Furthermore, although the etiology of colon cancer is attributed to diet (8), there has been no report which relates specific diets to fecal mutagens except for a statistical study showing that nonvegetarians have higher fecal mutagenicity than vegetarians (9 …”

Section: So2nh-oso 2ch 2ch20-cellulosementioning

confidence: 99%

“…The volume of each fraction was 3 mL. Fractions 1-3 were eluted with dilute formic acid at pH 3.0, fraction 4 with water, fractions [5][6][7] with 50% methanol, and fractions [8][9][10] with 50% methanol-ammonia at pH 11.0. The mutagenicity of each fraction was assayed on S. typhimurium TA 98 with S-9 mix, as described (3).…”

Section: Extraction Of Mutagens From Cooked Beefmentioning

confidence: 99%

Use of blue cotton for detection of mutagenicity in human feces excreted after ingestion of cooked meat.

Hayatsu¹,

Hayatsu²,

Wataya³

1986

Environ Health Perspect

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Fried ground beef has been shown to contain mutagens, and the major mutagenic component has been identified as . Mutagens in feces of three adult volunteers were fractionated by treatment of the feces with blue cotton followed by chromatography on a carboxymethyl cellulose column. The chromatographic fraction corresponding to MeIQx in terms of the position of elution was examined for mutagenicity in S. typhimurium TA 98 with metabolic activation. When meals containing no heated meat were eaten, this fraction of feces showed little or no mutagenicity. On eating fried ground beef, the feces excreted in the next 2 days showed greatly increased mutagenicity in this fraction. By eating no-meat meals subsequent to the meat meal, the mutagenicity resumed the original low level on the fourth day after the meat meal.The components in the mutagenic fraction were analyzed by high-pressure liquid chromatography, and were shown to differ from MeIQx. Blue CottonBlue cotton is absorbent cotton bearing covalently linked trisulfo-copper-phthalocyanine residues (1). It can adsorb in a specific manner organic compounds having three or greater numbers of fused aromatic rings (1). It is believed that the adsorption takes place by means of hydrophobic interactions between the copperphthalocyanine nucleus and the aromatic substances. There is evidence for this interaction: the visible spectrum of tetrasulfo-copper-phthalocyanine undergoes peak shifting on mixing with these compounds (unpublished work). Since many carcinogens and mutagens belong to this class of compounds, blue cotton is useful to isolate these compounds from crude materials. Mutagens which can be produced by cooking foods belong to this class (2) and they have strong affinity to blue cotton (1). As a result, blue cotton is especially suited for the isolation of mutagens from cooked foods such as fried ground beef (1,3). We show here that blue cotton is also useful for isolating mutagens from human feces excreted after ingestion of cooked meat. Fecal Mutagenicity and Mutagens in Cooked MeatMutagens in human feces have been a subject of intensive study (4). One of the purposes of these studies *Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700, Japan. SO2NH-OSO 2CH 2CH20-CelluloseBlue Cotton is to seek causes for colon cancer. Recently, fecapentaenes, which show mutagenicity towards Salmonella typhimurium TA 100 without metabolic activation, were isolated from human feces (5,6). The fecapentaenes are products of intestinal Bacteriodes, and investigation of the human populations gave no relationship between the fecal occurrence of these compounds and colon cancer (7). Furthermore, although the etiology of colon cancer is attributed to diet (8), there has been no report which relates specific diets to fecal mutagens except for a statistical study showing that nonvegetarians have higher fecal mutagenicity than vegetarians (9).On heating beef at high temperatures during cooking,

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On distribution of different fecapentaenes, the fecal mutagens, in the human population

Cited by 34 publications

References 5 publications

Bacterial infection as a cause of cancer.

Bacterial infection as a cause of cancer.

Inhibition of Carcinogenesis by minor Anutrient Constituents of the Diet

Use of blue cotton for detection of mutagenicity in human feces excreted after ingestion of cooked meat.

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