On Efficient Synthesis, X‐Ray Analysis and DPPH Radical Scavenging Activity of Pyrazolone‐Based trans‐Chalcones

Abstract

The present work highlights the facile and substantially streamlined microwave assisted synthesis of chalcones 3(a–m) from acetylpyrazolone 1 a and aldehyde 2(a–m) in piperidine‐ethanolic medium. The organocatalytic action of piperidine has been proposed in a mechanism. Different physical and analytical methods have been used to characterize the synthesized chalcones. Single Crystal XRD analyses of compounds 3 e and 3 f also supported proposed interpretation of the structural arrangements of these molecules. Further the synthesized compounds were evaluated for DPPH activity and results were compared with standard quercetin. Following compounds; 3 h, 3 i, 3 j and 3 d articulated excellent antioxidant activity.

Identification of Imidazolylpyrazole Ligands as Potent Urease Inhibitors: Synthesis, Antiurease Activity and In Silico Docking Studies

“…The mol files of the ligands (urease inhibitors) were created using ACD ChemSketch. For docking studies, standard steps of ligand and receptor preparation were followed using BioSolve IT's LeadIT software …”

“…This highlights the perpetual need of new improved inhibitors which could deal effectively with bacterial infections. Our research group has continuously been exploring biological potentials of different azolic compounds . As a continuation, herein, we discover an efficient series of urease inhibitors which could address the current desire of better anti‐urease drugs.…”

Sodium Alginate Biopolymer: An Efficient, Recyclable Green Catalyst for the Synthesis of Chalcone Derivatives under Mild Conditions

“…The presence of a reactive 𝛼, 𝛽 DOI: 10.1002/masy.202100428 unsaturated ketone functional group in chalcone is found to be responsible for their antimicrobial activity. [8][9][10][11][12][13] In the Claisen-Schmidt reaction, the concentration of alkali used, usually ranges between 10% and 60% or its carried out under strong acidic conditions. [14][15][16] The reaction is carried out at about 50 C for 12-15 h or at room temperature for almost 1 week.…”