We provide irreducibility criteria for compositions of multivariate polynomials over a field K, of the form f (X1, . . . , Xr−1, g(X1, . . . , Xr)), with both f and g in K[X1, . . . , Xr], for the case that f , viewed as a polynomial in Xr, has leading coefficient divisible by the k th power of an irreducible polynomial p(X1, . . . , Xr−1) of sufficiently large degree with respect to Xr−1, with k coprime to deg r f and deg r g.