On-line column coupled isotachophoresis-capillary zone electrophoresis hyphenated with tandem mass spectrometry in drug analysis: Varenicline and its metabolite in human urine

Piešťanský, Juraj; Maráková, Katarína; Veizerová, Lucia; Galba, Jaroslav; Mikuš, Peter

doi:10.1016/j.aca.2014.04.003

Cited by 20 publications

(23 citation statements)

References 22 publications

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“…The applicability of the method was demonstrated on the chiral separation and determination of pheniramine enantiomers in untreated human urine samples and provided LOQs at the level of 150 ng/L. Very similar sensitivities were reported with this method also for pheniramine and phenylephrine [63] and for varenicline [64].…”

Section: Online Itp-czementioning

confidence: 72%

Analytical capillary isotachophoresis after 50 years of development: Recent progress 2014–2016

2016

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This review brings a survey of papers on analytical ITP published since 2014 until the first quarter of 2016. The 50th anniversary of ITP as a modern analytical method offers the opportunity to present a brief view on its beginnings and to discuss the present state of the art from the viewpoint of the history of its development. Reviewed papers from the field of theory and principles confirm the continuing importance of computer simulations in the discovery of new and unexpected phenomena. The strongly developing field of instrumentation and techniques shows novel channel methodologies including use of porous media and new on-chip assays, where ITP is often included in a preseparative or even preparative function. A number of new analytical applications are reported, with ITP appearing almost exclusively in combination with other principles and methods.

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Section: Online Itp-czementioning

confidence: 72%

Analytical capillary isotachophoresis after 50 years of development: Recent progress 2014–2016

2016

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“…reported the use of on‐line column coupled ITP‐CZE‐triple quadrupole (QqQ) for Vereniciline and its metabolite in human urine with LOD and LOQ in the ng–pg/mL range by injecting unpretreated (and undiluted) urine samples . The same group then compared their method with hydrodynamic open CZE hyphenated with tandem MS for pheniramine and phynylephrine in human urine . They reported that ITP‐CZE‐ESI‐QqQ has higher sensitivity in comparison to the hydrodynamic open CZE‐ESI‐QqQ that only had a LOD and LOQ in pg/mL range for diluted urine.…”

Section: Stackingmentioning

confidence: 99%

Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2014–2016)

Breadmore

Wuethrich

et al. 2016

Electrophoresis

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One of the most cited limitations of capillary (and microchip) electrophoresis is the poor sensitivity. This review continues to update this series of biennial reviews, first published in Electrophoresis in 2007, on developments in the field of on-line/in-line concentration methods in capillaries and microchips, covering the period July 2014-June 2016. It includes developments in the field of stacking, covering all methods from field amplified sample stacking and large volume sample stacking, through to isotachophoresis, dynamic pH junction, and sweeping. Attention is also given to on-line or in-line extraction methods that have been used for electrophoresis.

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“…The use of a maximum capillary temperature and application voltage results in joule heating, which causes peak broadening and a current drop in the capillary [25]. Therefore, the effects of three different application voltages and three different capillary temperatures (15,20, and 25 °C) on the migration times were evaluated simultaneously. The observed migration times for VT and IS at different application voltages and capillary temperatures are given in Figure 3.…”

Section: Optimization Of Instrument Parametersmentioning

confidence: 99%

“…Therefore, the method developed in this study was fully validated, including robustness and ruggedness testing. Another reported method for the determination of varenicline in human urine also used CE coupled with tandem mass spectrometry (MS) [15]. However, the aim of this study is to develop a simple and rapid CE method.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a capillary electrophoresis method for routine determination of varenicline tartrate in quality control laboratories

Çelebi̇er

Koçak

Altınöz

2015

Maced. J. Chem. Chem. Eng.

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In this study, analyses were carried out on a fused-silica capillary (i.d. 50.0 µm, total length 48.5 cm, and effective length 40.0 cm) in normal mode by applying a voltage of 20 kV. Sample injections were made in hydrodynamic mode over 7 s under a pressure of 50 mbar. The capillary temperature was set at 35 ºC and the detection was performed at a wavelength of 205 nm. The background electrolyte was 40 mM citrate buffer at pH 6.0 and the internal standard was labetalol hydrochloride. The total analysis time was shorter than 5 minutes. The method was validated according to the International Conference on Harmonization (ICH) guidelines, and the method was found to be linear, precise, accurate, specific, robust, and rugged. The linearity range was found to be 1.0-60.0 µg ml -1 and the limit of detection and quantitation were 0.5 and 1.0 µg ml -1 , respectively. The developed method was proposed for quality-control laboratories.Keywords: capillary electrophoresis; varenicline tartrate; analytical method validation; pharmaceutical dosage forms; quality control ЕВАЛУАЦИЈА НА МЕТОДОТ НА КАПИЛАРНА ЕЛЕКТРОФОРЕЗА ЗА РУТИНСКО ОПРЕДЕЛУВАЊЕ ВАРЕНИКЛИН ТАРТАРАТ ВО ЛАБОРАТОРИИ ЗА КОНТРОЛА НА КВАЛИТЕТВо оваа студија извршена е анализа на капилара од фузирана силика (в.д. 50.0 µm, должина 48,5 cm и ефективна должина 40,0 cm) во нормален мод со примена на напон од 20 kV. Инјектирањето на примероците беше вршено во хидродинамичен мод во времетраење од 7 s под притисок од 50 mbar. Температурата на капиларата беше на 35 ºC и детекцијата беше вршена на бранова должина од 205 nm. Беше користен 40 mM цитратен пуфер на pH 6.0 како електролит на матрицата, додека како внатрешен стандард беше користен лабеталол-хидрохлорид. Вкупното време на анализа беше под 5 минути. Методот беше валидиран според препораките на Меѓународната конференција за хармонизација (International Conference on Harmonization -ICH) при што беше утврдено дека методот е линеарен, прецизен, точен, специфичен, робустен и отпорен. Линеарниот опсег изнесува 1.0-60.0 µg ml -1 , додека прагот на детекција и квантификација изнесуваа соодветно 0.5 и 1.0 µg ml -1 . Разработениот метод е предложен за лаборатории за контрола на квалитет.Клучни зборови: капиларна електрофореза; вареницилин тартарат; валидација на аналитички метод; фармацевтско дозирање; контрола на квалитет

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On-line column coupled isotachophoresis-capillary zone electrophoresis hyphenated with tandem mass spectrometry in drug analysis: Varenicline and its metabolite in human urine

Cited by 20 publications

References 22 publications

Analytical capillary isotachophoresis after 50 years of development: Recent progress 2014–2016

Analytical capillary isotachophoresis after 50 years of development: Recent progress 2014–2016

Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2014–2016)

Evaluation of a capillary electrophoresis method for routine determination of varenicline tartrate in quality control laboratories

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