On line determination of airway resistance by plethysmography and microcomputer

Lorino, A. M.; Lorino, H.; Mariette, C.; Pelle, Gabriel; Harf, Alain; Atlan, G

doi:10.1016/0010-4825(85)90061-7

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…Selection criteria included: (i) a history of cigarette smoking of at least 15 packyears, (ii) airflow limitation with a forced expiratory flow at 50% of vital capacity of less than 70% of the predicted value, as measured from a maximum expiratory flow-volume curve (Quanjer et al, 1983), (iii) an increase of at least 20% in specific airway conductance (sGaw) following two inhalations of 100 ,ug salbutamol each. Exclusion criteria included any history Lorino et al (1985). For the measurements, the subjects panted at a frequency of about 2 cycles S-1 at a thoracic gas volume close to their functional residual capacity.…”

Section: Subjectsmentioning

confidence: 99%

Comparative effects of bisoprolol and acebutolol in smokers with airway obstruction.

Macquin‐Mavier¹,

Roudot-Thoraval²,

Clérici³

et al. 1988

Brit J Clinical Pharma

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1. The effects of single oral doses of 10 mg bisoprolol and 400 mg acebutolol on respiratory function were studied in nine smokers with airway obstruction in a double‐blind, placebo‐controlled experiment. 2. The effects of the drugs were assessed by measuring specific airway conductance (sGaw) for 3 h after their administration and by studying their interaction with the bronchodilator response to inhaled salbutamol. 3. sGaw did not change for 3 h after bisoprolol or acebutolol administration. The bronchodilator response to inhaled salbutamol was not affected by bisoprolol but significantly reduced by acebutolol (P less than 0.05 vs placebo). 4. Under these conditions, bisoprolol behaves like a selective beta 1‐adrenoceptor antagonist but acebutolol exhibits less beta 1‐adrenoceptor selectivity.

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Section: Subjectsmentioning

confidence: 99%

Comparative effects of bisoprolol and acebutolol in smokers with airway obstruction.

Macquin‐Mavier¹,

Roudot-Thoraval²,

Clérici³

et al. 1988

Brit J Clinical Pharma

Self Cite

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Real-time detection of ventilatory meaneuvers by a microcomputer

Lorino¹,

Lorino²,

Mariette³

et al. 1986

Computer Methods and Programs in Biomedicine

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Comparison of the dose-response curves obtained by forced oscillation and plethysmography during carbachol inhalation

Chinet

Pelle²,

Macquin‐Mavier³

et al. 1988

Eur Respir J

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We compared the cumulative dose-response curves obtained during carbachol inhalation by simultaneous measurements of airway specific conductance (sGaw) and respiratory conductance, in 23 subjects with or without bronchial hyperresponsiveness. The sGaw was measured by a body plethysmograph, whilst the random noise forced oscillation technique (FOT) was used to determine respiratory conductance. The sGaw was compared to respiratory conductance extrapolated to zero frequency (Grs0). Bronchial sensitivity was assessed by the threshold dose of carbachol (TD) that induced a decrease in sGaw and Grs0 of twice the baseline coefficient of variation. Bronchial responsiveness was assessed by the slopes (S) of the individual dose-response curves. The TD and S values obtained by FOT and by plethysmography were closely correlated (p less than 0.001). The carbachol doses inducing a 50% reduction in sGaw were equivalent to those causing a 42% reduction in Grs0 (r = 0.90; p less than 0.001). During bronchial challenge testing, FOT provides comparable information in terms of bronchial sensitivity and responsiveness to that supplied by plethysmography.

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On line determination of airway resistance by plethysmography and microcomputer

Cited by 4 publications

References 11 publications

Comparative effects of bisoprolol and acebutolol in smokers with airway obstruction.

Comparative effects of bisoprolol and acebutolol in smokers with airway obstruction.

Real-time detection of ventilatory meaneuvers by a microcomputer

Comparison of the dose-response curves obtained by forced oscillation and plethysmography during carbachol inhalation

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