2011
DOI: 10.1016/j.compchemeng.2010.05.005
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On-line estimation in a distributed parameter bioreactor: Application to the gluconic acid production

Abstract: This work presents a methodology which exploits the underlying biochemical structure of bioprocesses to estimate concentrations in aerobic fermenters from oxygen measurements. Although a number of estimators have been proposed over the years in the literature, the methodology proposed in this work is able to operate in transient conditions while does not require the knowledge of the growth kinetics. In addition, it can be also applied to fermenters where the spatial distribution of the concentrations is releva… Show more

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Cited by 4 publications
(2 citation statements)
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“…The controls may take values between: 0, when closed and 1, when opened. Mathematically the process may be described as follows [21]:…”
Section: Model Identification: Production Of Gluconic Acid In a Fed-bmentioning
confidence: 99%
“…The controls may take values between: 0, when closed and 1, when opened. Mathematically the process may be described as follows [21]:…”
Section: Model Identification: Production Of Gluconic Acid In a Fed-bmentioning
confidence: 99%
“…Attempts to arrange the parameters of a model in a hierarchy have been presented in Chis et al, Rodríguez‐Fernández et al, Solimeno et al, García et al, and Senthamaraikkannan et al These contributions are mainly based on sensitivity analysis but without exploiting parameter ranking. In Balsa‐Canto et al for example, a local sensitivity analysis is used to obtain a ranking of the most relevant parameters to conduct a practical identifiability analysis and optimal experimental design.…”
Section: Introductionmentioning
confidence: 99%