On-line quantitative assessment of left ventricular filling during dobutamine stress echocardiography: a useful addition to conventional wall motion scoring

Preliminary clinical study of real-time three-dimensional echocardiographic volume-time curve in evaluating left ventricular diastolic function

“…Such volume-time curve (VTC) analysis permits determination of clinically important parameters such as peak ejection rate and peak rapid filling rate, which can be used for the evaluation of diastolic function. Various techniques can generate VTC, such as ventriculography, magnetic resonance imaging (MRI), two-dimensional echocardiography [2,3,14] . To analyze VTC, 2 prerequisites are necessary: (1) accurate determination of LV volume throughout the cardiac cycle and (2) registration of LV volumes in real-time to prevent sampling errors during VTC reconstruction over multiple cardiac cycles.…”

“…To analyze VTC, 2 prerequisites are necessary: (1) accurate determination of LV volume throughout the cardiac cycle and (2) registration of LV volumes in real-time to prevent sampling errors during VTC reconstruction over multiple cardiac cycles. Standard techniques like two-dimentional echocardiography and ventriculography provide real-time imaging but volume estimation is potentially inaccurate as a result of invalid geometric assumption of the LV shape [14] . On the other hand, MRI and CT can allows accurate determination of LV volume but require extended image sampling over multiple cardiac cycles preventing real-time VTC generation [3] .…”

Methodological Analysis of Diagnostic Dobutamine Stress Echocardiography Studies

“…Two investigators (BJK, MLG) independently screened the 44 articles 3–46 that met the inclusion criteria for abstracted variables and the methodological standards described below. Variables abstracted from each report included identifying information (first author, year of publication) and clinical characteristics (number of patients, mean age, percentage of male patients).…”

Real-Time Three-Dimensional Echocardiography for Improved Evaluation of Diastolic Function Using Volume-Time Curves

“…Poliner et al [16] found in a group of patients with good left ventricular systolic function that the exercise to rest ratio for peak-filling-rate was greater than one in patients with normal coronary arteries and one or less for patients with diseased coronary arteries with sensitivity of 98% and specificity of 94% for detecting coronary artery disease. Vitarelli et al [28] by using 2-D echo with automated boundary detection applied parameters of diastolic filling rates to conventional dobutamine stress echo. In this study, in a subgroup of patients with single coronary artery disease the sensitivity of detecting coronary artery disease was significantly increased from 68% to 91%, whereas the sensitivity was not changed significantly in the overall group of patients with coronary artery disease.…”