No abstract

T-DSE with TDI is a feasible and accurate test for the quantitative assessment of patients with CAD who have impaired augmentation of systolic and diastolic myocardial velocities during dobutamine infusion.

In order to assess the role of the pulmonary venous flow (PVF) velocity pattern in the evaluation of patients with congestive heart failure (CHF), we studied 41 CHF patients by means of transthoracic echocardiography (TTE) and multiplane transesophageal echocardiography (TEE). The etiology of CHF was idiopathic or ischemic dilated cardiomyopathy in 19 patients and hypertensive heart disease in 22. Sixteen subjects without cardiovascular disease were selected as normal controls. PVF peak systolic and peak early diastolic (D) velocities were recorded by TEE and TTE and the systolic fraction (SF) was measured (i.e., the systolic velocity-time integral – VTI – expressed as a fraction of the sum of systolic and early diastolic VTI). TEE tracings were obtained in all patients and had more laminar-appearing spectral signals, thus were used for analysis. By TTE the mitral flow velocity patterns were also evaluated: peak early diastolic velocity (E), peak velocity at atrial contraction, E velocity normalized for VTI (E/VTI), deceleration time (DT), and left ventricular isovolumic relaxation time (LVIRT). The left ventricular ejection fraction (LVEF) was calculated by two-dimensional echocardiographic images using the modified Simpson method. The SF was lower in CHF patients as compared with normal controls (p < 0.0001). The E/VTI ratio was higher, and DT and LVIRT were shorter (p < 0.0001) in CHF patients. A significant correlation was observed between SF and LVEF in CHF patients (r = 0.76, p < 0.001). Two different PVF velocity patterns (type A: SF < 0 50%, D > 50 cm/s; type B: SF ∼ 50%, D > 50 cm/s) were recognized in patients with a low LVEF (type A) and a nearly normal or normal LVEF (type B). Patients with LVEF < 40% showed mean SF values significantly lower than patients with LVEF > 40% (33.26 ± 10.84 vs. 51.00 ± 4.00%, p < 0.0001). Mean DT and LVIRT values were not significantly different in patients with LVEF < 40% and > 40%. Thus in CHF patients TEE PVF velocity patterns help in distinguishing patients with systolic dysfunction (low LVEF and SF) from patients with predominant diastolic impairment (normal or nearly normal LVEF, high D velocities).

To define the accuracy of real-time two-dimensional echocardiographic imaging with automatic border detection (ABD) for the assessment of right atrial volume and function, we studied with ABD echocardiography 29 healthy subjects and 43 patients with sinus rhythm and various forms of heart disease. Twenty-three patients had right ventricular (RV) dysfunction (fractional area change < 45%), and 20 had RV hypertrophy from pressure overload. Doppler color flow imaging disclosed moderate-to-severe tricuspid regurgitation (TR) in 20 patients and trivial or no TR in 23. The ABD-derived end-diastolic (EDV) and end-systolic (ESV) volumes by the method of discs were used to compute fractional indexes of right atrial (RA) volume changes. Right atrial emptying fraction (RAEF) percent [(ESV - EDV)/ESV x 100] was calculated. The ABD-derived EDV and ESV correlated well with conventional offline measurements of two-dimensional echocardiographic images in the 43 patients (r = 0.94 for the end-diastolic values; r = 0.93 for the end-systolic values). Intraobserver and interobserver variability showed a high correlation between different measurements (r = 0.97 and 0.90, respectively). RA volumes were significantly higher in the patient population than in the control subjects (148.9 +/- 66.7 ml vs 43.1 +/- 9.2 ml, P < 0.0001). The right atrial emptying fraction (RAEF) was higher in patients with RV pressure overload than in normal subjects (61% +/- 11% vs 46% +/- 9%, P < 0.05) and lower in those with RV dysfunction than in the control subjects (29% +/- 7% vs 46% +/- 9%, P < 0.01). In both groups (RV pressure overload and RV dysfunction), RAEF was higher in patients without or with trivial TR compared with those with significant TR (29% +/- 7% vs 23% +/- 6%; 61% +/- 11% vs 42% +/- 7%; P < 0.05). Thus, changes in right atrial volume and function can be measured noninvasively by the ABD method. This imaging technique may prove to be useful for assessing right atrial size and function under different physiological and pathological conditions and for identifying factors that influence atrial function in right ventricular diseases.

SummaryBuckground: Color kinesis (CK) is a recently developed echocardiographic technique based on acoustic quantification that automatically tracks and displays endocardial motion in real time and has been used in initial studies to improve the evaluation of global and regional wall motion.Hypothesis: For further validation of the use of CK for analysis of segmental ventricular dysfunction, we assessed its sensitivity and specificity for detection of regional systolic and diastolic wall motion abnormalities in patients with coronary artery disease (CAD).Methods: Two-dimensional (2-D) echocardiography and CK were used to study 15 normal subjects and 63 patients with technically g o d quality echocardiographic tracings, who underwent coronary arteriography within 1 month of echocardiography. Significant (> 70% luminal diameter stenosis) CAD was present in 50 patients (79%).Results: Color kinesis tracked endocardial motion accurately in 93% of left ventricular segments. Wall motion score, systolic segmental endocardal motion (SEM), and the time of systolic SEM (tSEM) and diastolic (tDEM) segmental endocardial motion were calculated. Intra-and interobcerver variability were within narrow limits. SEM and tSEM were significantly lower and tDEM was significantly higher in the patient population than in the control group (p< 0.001). Comparison between CK and 2-D echocardiography showed a correlation coefficient of 0.8 1 between the two techniques. The score was identically graded in 74% of segments, with concordance of 82% in diagnosing segments as abnomial. Interobserver concordance was 86% for CK (r = 0.85) and 8 1% for 2-D echocardiography (r = 0.80). The sensitivity and specificity of systolic and diastolic CK parameters for the detection of CAD were 88 and 92% and 77 and 8596, respectively. The positive predictive values were 93 and 96%, respectively, the negative predictive values were 63 and 73%, respectively, and the overall accuracy was 86 and 9 1 %, respectively.Conclusions: Our data suggest that CK is a feasible and sensitive technique for identifying regional systolic as well as diastolic wall motion abnormalities in patients with CAD.