On molecular asymmetry in living organisms

Ageno, M.

doi:10.1016/0022-5193(72)90125-7

Cited by 19 publications

(7 citation statements)

References 22 publications

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“…It is to be noted that another important aspect along with the polarities of the amino acids and their functional forms (canonical or zw configuration) is the effect of chirality or handedness on the nature of interaction with Au clusters. For biological function and activity, chirality plays a vital role, and that explains the preferentiality for l -amino acid in proteins and d -sugars in DNA, attributed to genetic evolution and natural selection . The biological self-assembly at the nanoscale is also controlled by enantiospecific molecular interactions that can be tailored for applications in enantioselective heterogeneous catalysis, optical activity, chiral separations, and molecular sensing. , In this context, the chirality of the amino acids is significant when they interact with other chiral molecules or chiral Au n nanoclusters.…”

Section: Resultsmentioning

confidence: 99%

Amino-Acid-Conjugated Gold Clusters: Interaction of Alanine and Tryptophan with Au₈ and Au₂₀

et al. 2017

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The stability and electronic properties of gold (Au) clusters interacting with the amino acids alanine (Ala) and tryptophan (Trp) in their canonical and zwitterionic configurations were investigated using first-principles density functional theory (DFT). We found that the geometrical structures of the Au clusters and the polarities of the amino acids determine the nature of the interactions in the gas and solvent phases. In the gas phase, the Au8 (D 4h ) and Au20 (T d ) clusters prefer single-site interactions through the amine group for the canonical amino acids, whereas in the solvent phase, the carboxylic site is preferred for the zwitterionic amino acids. The limited screening of the intermolecular interactions introduced by the solvent medium for the canonical forms of Ala and Trp conjugated with the Au n complexes suggests that the bonding is primarily covalent in nature. The screening is significantly more pronounced for the zwitterionic complexes for which the electrostatic interactions dominate. The cluster sizes and configurations define the extent of the interactions and the overall stability of the complexes. The structures of the Au n clusters govern the charge distribution and electrostatic potential, directing the selectivity toward the preferential binding sites with the Ala and Trp amino acids.

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Section: Resultsmentioning

confidence: 99%

Amino-Acid-Conjugated Gold Clusters: Interaction of Alanine and Tryptophan with Au₈ and Au₂₀

et al. 2017

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“…Last but not least, a daring idea about a transition from a geochemical to a biochemical world that might have originated in two mirrored forms has been put forward (Ageno, 1972).…”

Section: Mirrored Worldsmentioning

confidence: 99%

Symmetry breaking and functional incompleteness in biological systems

Korenić

Perović

Ćirković

et al. 2020

Progress in Biophysics and Molecular Biology

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“…Some early carcinologists, however, suggested that asymmetry was a predetermined condition (Rathke 1842;Agassiz 1875;Thompson 1903;Boas 1926). Although all animals have been said to be asymmetrical at the molecular level (Ageno 1972;Neville 1976), sym-metry is generally considered to be the primitive orplesiomorphic condition (Bouvier 1940;Scholtz & Richter 1995;Palmer 1996). However, when symmetry is encountered among paguroids, it has been assumed to have been secondarily acquired (Bouvier 1940;Russell 1962;Elwood & Neil 1992; Richter & Scholtz 1994).…”

Section: Questions Of Asymmetrymentioning

confidence: 99%

Carcinization in the Anomura – fact or fiction? II. Evidence from larval, megalopal and early juvenile morphology

McLaughlin

Lemaitre

Tudge

2004

CTOZ

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In this second of a two-part series, carcinization in the Anomura has been reviewed from early juvenile, megalopal, and larval perspectives. Data from megalopal and early juvenile development in ten genera of the Lithodidae have provided unequivocal evidence that earlier hypotheses regarding evolution of the king crab pleon were erroneous. A pattern of sundering, and decalcification has been traced from the megalopal stage through several early crabs stages in species of Lithodes and Paralomis, with supplemental evidence from species in eight other genera. Of major significance has been the attention directed to the Marginal plates of the second pleomere, which when separeted in lithodids are not homologous with the adult so-called “marginal plates” of the following three tergites. Auxiliary megalopal and early juvenile lithodid data, as well as equivalent data from other paguroids, support the evolutionary direction indicated by lithodid pleonal plate development. Therefore, while carcinization, or development of a crab-like body form, has occurred in the Lithodidae, it has not proceeded from a hermit crab ancestor. Rather the data suggest the reverse, thus effectively refuting the “hermit to king” myth. Brief reviews of data available from the Lomisidae and Porcellanidae support the proposition of independent anomuran carcinization events in these taxa as well. Results of cladistic analysis of megalopal and juvenile data, although somewhat unconventional, do not support the claim of a sister-group relation of the lithodid genera Lithodes and Paralithodes with the pagurid genus Pagurus. Attempts to subject larval phase data to similar analysis were thwarted by the tendency in paguroids, including lithodids, for lecithotrophic development. Additionally, presumed initial and terminal stage deletions disallow the ontogenetic stage homologies required for meaningful phylogenetic results.

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On molecular asymmetry in living organisms

Cited by 19 publications

References 22 publications

Amino-Acid-Conjugated Gold Clusters: Interaction of Alanine and Tryptophan with Au₈ and Au₂₀

Amino-Acid-Conjugated Gold Clusters: Interaction of Alanine and Tryptophan with Au₈ and Au₂₀

Symmetry breaking and functional incompleteness in biological systems

Carcinization in the Anomura – fact or fiction? II. Evidence from larval, megalopal and early juvenile morphology

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On molecular asymmetry in living organisms

Cited by 19 publications

References 22 publications

Amino-Acid-Conjugated Gold Clusters: Interaction of Alanine and Tryptophan with Au8 and Au20

Amino-Acid-Conjugated Gold Clusters: Interaction of Alanine and Tryptophan with Au8 and Au20

Symmetry breaking and functional incompleteness in biological systems

Carcinization in the Anomura – fact or fiction? II. Evidence from larval, megalopal and early juvenile morphology

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Product

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Amino-Acid-Conjugated Gold Clusters: Interaction of Alanine and Tryptophan with Au₈ and Au₂₀

Amino-Acid-Conjugated Gold Clusters: Interaction of Alanine and Tryptophan with Au₈ and Au₂₀