Priced timed automata (PTA) are discrete-event system models with temporal constraints and a cost function and are used to pose optimal scheduling and routing problems. To date, solutions to these problems have been found offline and executed open loop. This open-loop control strategy makes it impossible to account for disturbances, i.e., changes in costs or scheduling constraints over time. To address this shortcoming, this work's first contribution is a closed-loop model predictive control (MPC) framework for PTA, enabling decision-making based on real-time model updates. To ensure the feasibility of an MPC problem, it is often desirable to soften constraints. However, the contemporary PTA theory does not consider soft constraints. Thus, this work's second contribution is to integrate constraint softening with PTA control by harnessing the capabilities of new solvers enabled by the recasting of the models and control problem into first-order logic by employing modified encoding schemes based on existing works. Finally, the proposed control framework and implementation are demonstrated in a simulation case study on the guidance of a product through a manufacturing system.