On/off-switchable LSPR nano-immunoassay for troponin-T

Ashaduzzaman, Md.; Deshpande, Swapneel R.; Murugan, N.; Mishra, Yogendra Kumar; Turner, Anthony; Tiwari, Ashutosh

doi:10.1038/srep44027

Cited by 43 publications

(30 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Very recently different kinds of functional and sustainable materials are being explored for their usage in a number of applications ranging from biomedical, automotive to aerospace [1] [2,3] [4][5][6]. Especially in the field of biomedical, the ongoing tendencies in the clinico-surgical field are directed towards the development and promotion of a rising generation of ceramic biomaterials solely dedicated for bone restoration.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis and characterization of hydroxyapatite particles for high value nanocomposites and biomaterials

Miculescu

Mocanu

Dascălu

et al. 2017

Vacuum

View full text Add to dashboard Cite

Lately Hydroxyapatite has gained a lot of research interest and intense focus due to its structural as well as compositional similarity to the components of human bone mineral. The conversion of calcium-rich precursors to hydroxyapatite could lead to the development of a new sustainable alternative with a valuable environmental and socioeconomically impact. Still, current approaches faces lots of challenges in terms of synthesis parameters compatible to a reproducible route for calcium phosphates (hydroxyapatite included) synthesis. The optimization of Rathje synthesis route and

show abstract

Section: Introductionmentioning

confidence: 99%

Facile synthesis and characterization of hydroxyapatite particles for high value nanocomposites and biomaterials

Miculescu

Mocanu

Dascălu

et al. 2017

Vacuum

View full text Add to dashboard Cite

show abstract

“…In a different approach, the LSPR mechanism has been utilized for the development of analytical methods for the detection of protein biomarkers [34][35][36]. In typical LSPR-based analytical methods, the bio/chemical interaction on the surface of metallic nanoparticles leads to an increase of the refractive index of a local medium, resulting in a resonant wavelength shift.…”

Section: Analytical Methods For Protein Biomarkersmentioning

confidence: 99%

Noble Metal-Assisted Surface Plasmon Resonance Immunosensors

Choi

Lee

Son

et al. 2020

Sensors

View full text Add to dashboard Cite

For the early diagnosis of several diseases, various biomarkers have been discovered and utilized through the measurement of concentrations in body fluids such as blood, urine, and saliva. The most representative analytical method for biomarker detection is an immunosensor, which exploits the specific antigen-antibody immunoreaction. Among diverse analytical methods, surface plasmon resonance (SPR)-based immunosensors are emerging as a potential detection platform due to high sensitivity, selectivity, and intuitive features. Particularly, SPR-based immunosensors could detect biomarkers without labeling of a specific detection probe, as typical immunosensors such as enzyme-linked immunosorbent assay (ELISA) use enzymes like horseradish peroxidase (HRP). In this review, SPR-based immunosensors utilizing noble metals such as Au and Ag as SPR-inducing factors for the measurement of different types of protein biomarkers, including viruses, microbes, and extracellular vesicles (EV), are briefly introduced.

show abstract

“…This displacement sets up a restoring force leading to coherent oscillations of the charge density, and hence, a resonant frequency. This is termed localised surface plasmon resonance (LSPR) and has been widely researched and applied in sensors [4][5][6][7], solar cells [8,9], and spectroscopy [10].…”

Section: Introductionmentioning

confidence: 99%

Infra-Red Plasmonic Sensors

Centeno

Aid²,

Xie

2018

Chemosensors

View full text Add to dashboard Cite

Plasmonic sensors exploiting the localized surface plasmon resonance (LSPR) of noble metal nanoparticles are common in the visual spectrum. However, bio-sensors near the infra-red (NIR) windows (600-900 nm and 1000-1400 nm) are of interest, as in these regions the absorption coefficients of water, melanin deoxyglobin, and hemoglobin are all low. The first part of this paper reviews the work that has been undertaken using gold (Au) and silver (Ag) particles in metal enhanced fluorescence (MEF) in the NIR. Despite this success, there are limitations, as there is only a narrow band in the visual and NIR where losses are low for traditional plasmonic materials. Further, noble metals are not compatible with standard silicon manufacturing processes, making it challenging to produce on-chip integrated plasmonic sensors with Au or Ag. Therefore, it is desirable to use different materials for plasmonic chemical and biological sensing, that are foundry-compatible with silicon (Si) and germanium (Ge). One material that has received significant attention is highly-doped Ge, which starts to exhibit metallic properties at a wavelength as short as 6 µm. This is discussed in the second part of the paper and the results of recent analysis are included.Fluorescent molecules emitting at wavelengths in the infra-red window, in which penetration depth is high and the autofluorescence minimum is of particular interest, are potentially an attractive technology for bio-applications [27]. However, the low quantum yield and poor photostability of near infra-red (NIR) dyes currently limits their applicability. Design and synthesis of NIR dyes with high quantum yield and photostability have proved to be extremely challenging, due to the complex synthetic routes required for these large, complex molecules [27]. The amplification of light from NIR fluorophores by MEF is a promising strategy for dramatically improving both the detection sensitivity and image enhancement, thereby realizing the potential advantages of the NIR fluorophores. Section 2 of this paper discusses the physical process of MEF and reviews some of the published work by the authors.NIR losses arise in Au and Ag from intraband (or Drude) losses. There is, therefore, only a narrow band in the visual and NIR range where losses are low for traditional plasmonic materials. A further challenge associated with noble metals is that they are not compatible with standard silicon manufacturing processes. Further, noble metals diffuse into the semiconductor, forming deep-level traps which have an adverse effect on device performance. While Au and Ag are the obvious choice for visible and NIR applications, there is a desire and need for chemical and biological sensing in the mid-infrared (MIR) range [29][30][31] using materials that are foundry-compatible with silicon (Si) and germanium (Ge), that might lead to on-chip integration of devices governed by plasmonic effects [25,26]. One material that has received significant attention as a potential plasmonic material in the MIR is highly-...

show abstract

On/off-switchable LSPR nano-immunoassay for troponin-T

Cited by 43 publications

References 52 publications

Facile synthesis and characterization of hydroxyapatite particles for high value nanocomposites and biomaterials

Facile synthesis and characterization of hydroxyapatite particles for high value nanocomposites and biomaterials

Noble Metal-Assisted Surface Plasmon Resonance Immunosensors

Infra-Red Plasmonic Sensors

Contact Info

Product

Resources

About