Multiple Input Multiple Output (MIMO) adds a new dimension, the spatial one, to be optimized in Cognitive Radio (CR) by offering service simultaneously to more than one user. In this paper, statistical optimization techniques are applied to assess the performance of the Quality of Experience (QoE) in CR systems, where each user has different demands. A Multiuser scenario is considered where the transmitter can accomplish either a random or an opportunistic scheduling approach. Closed form expressions are derived for different scenarios and obtained for three QoE indicators in the system. The performance of primary and secondary users in such scenarios are mathematically formulated and compared their results to computer simulations.Index Terms-Quality of experience, multiuser MIMO, cognitive radio.