On structure and mechanics of biomimetic meta-biomaterials fabricated via metal additive manufacturing

Tilton, Maryam; Borjali, Alireza; Isaacson, Aaron; Varadarajan, Kartik M.; Manogharan, Guha

doi:10.1016/j.matdes.2021.109498

Cited by 21 publications

(7 citation statements)

References 68 publications

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“…By contrast, the elastic modulus and mechanical strength are highly reliant on the porosity [21]. Recent advances in manufacturing techniques, including selective later melting and electron beam melting, have attracted a great deal of attention due to their ability to control the internal structure of porous Ti [22,23]. Among the surface modifications described above, heat treatment and solution are both cost-effective and stimulate the formation of a uniform bioactive surface layer, even on the inner surface of a porous body [24,25].…”

Section: Introductionmentioning

confidence: 99%

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Iodine-Loaded Calcium Titanate for Bone Repair with Sustainable Antibacterial Activity Prepared by Solution and Heat Treatment

Yamaguchi

Shintani

et al. 2021

Nanomaterials

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In the orthopedic and dental fields, simultaneously conferring titanium (Ti) and its alloy implants with antibacterial and bone-bonding capabilities is an outstanding challenge. In the present study, we developed a novel combined solution and heat treatment that controllably incorporates 0.7% to 10.5% of iodine into Ti and its alloys by ion exchange with calcium ions in a bioactive calcium titanate. The treated metals formed iodine-containing calcium-deficient calcium titanate with abundant Ti-OH groups on their surfaces. High-resolution XPS analysis revealed that the incorporated iodine ions were mainly positively charged. The surface treatment also induced a shift in the isoelectric point toward a higher pH, which indicated a prevalence of basic surface functionalities. The Ti loaded with 8.6% iodine slowly released 5.6 ppm of iodine over 90 days and exhibited strong antibacterial activity (reduction rate >99%) against methicillin-resistant Staphylococcus aureus (MRSA), S. aureus, Escherichia coli, and S. epidermidis. A long-term stability test of the antibacterial activity on MRSA showed that the treated Ti maintained a >99% reduction until 3 months, and then it gradually decreased after 6 months (to a 97.3% reduction). There was no cytotoxicity in MC3T3-E1 or L929 cells, whereas apatite formed on the treated metal in a simulated body fluid within 3 days. It is expected that the iodine-carrying Ti and its alloys will be particularly useful for orthopedic and dental implants since they reliably bond to bone and prevent infection owing to their apatite formation, cytocompatibility, and sustainable antibacterial activity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Iodine-Loaded Calcium Titanate for Bone Repair with Sustainable Antibacterial Activity Prepared by Solution and Heat Treatment

Yamaguchi

Shintani

et al. 2021

Nanomaterials

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“…Further investigation in establishing an effective post-processing protocol is recommended to eliminate any entrapped powder particles in the implant after vigorous cleaning and sterilization process. Additionally, future studies should further investigate alternative approaches to minimize or eliminate presence of trapped powder particles in such implants, either by replacing beam-based unit cells with surface-based topologies (e.g., minimal surfaces) [54,55] or changing the manufacturing method.…”

Section: Physical and Morphological Propertiesmentioning

confidence: 99%

Additively manufactured patient-specific prosthesis for tumor reconstruction: Design, process, and properties

et al. 2021

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Design and processing capabilities of additive manufacturing (AM) to fabricate complex geometries continues to drive the adoption of AM for biomedical applications. In this study, a validated design methodology is presented to evaluate AM as an effective fabrication technique for reconstruction of large bone defects after tumor resection in pediatric oncology patients. Implanting off-the-shelf components in pediatric patients is especially challenging because most standard components are sized and shaped for more common adult cases. While currently reported efforts on AM implants are focused on maxillofacial, hip and knee reconstructions, there have been no reported studies on reconstruction of proximal humerus tumors. A case study of a 9-year-old diagnosed with proximal humerus osteosarcoma was used to develop a patient-specific AM prosthesis for the humerus following tumor resection. Commonly used body-centered cubic (BCC) structures were incorporated at the surgical neck and distal interface in order to increase the effective surface area, promote osseointegration, and reduce the implant weight. A patient-specific prosthesis was fabricated using electron beam melting method from biocompatible Ti-6Al-4V. Both computational and biomechanical tests were performed on the prosthesis to evaluate its biomechanical behavior under varying loading conditions. Morphological analysis of the construct using micro-computed tomography was used to compare the as-designed and as-built prosthesis. It was found that the patient-specific prosthesis could withstand physiologically-relevant loading conditions with minimal permanent deformation (82 μm after 105 cycles) at the medial aspect of the porous surgical neck. These outcomes support potential translation of the patient-specific AM prostheses to reconstruct large bone defects following tumor resection.

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“…In fact, with respect to conventional subtractive or formative manufacturing techniques, the main advantages of metal AM processes (i.e., powder bed fusion (PBF) technologies) are the fast design and manufacture of complex-shaped, customizable (patient-specific) porous structures [ 8 , 9 ]. In this sense, relevant steps can be taken toward a partial or complete mimicking of the morphological structure of bone tissue, and its peculiar hierarchical configuration, using architected cellular materials [ 10 , 11 , 12 ]. These structures consist of repeating cell units spatially arranged in a distinct pattern.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Ti6Al4V/Silk Fibroin Composite for Load-Bearing Implants: A Hierarchical Multifunctional Cellular Scaffold

et al. 2022

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Despite the tremendous technological advances that metal additive manufacturing (AM) has made in the last decades, there are still some major concerns guaranteeing its massive industrial application in the biomedical field. Indeed, some main limitations arise in dealing with their biological properties, specifically in terms of osseointegration. Morphological accuracy of sub-unital elements along with the printing resolution are major constraints in the design workspace of a lattice, hindering the possibility of manufacturing structures optimized for proper osteointegration. To overcome these issues, the authors developed a new hybrid multifunctional composite scaffold consisting of an AM Ti6Al4V lattice structure and a silk fibroin/gelatin foam. The composite was realized by combining laser powder bed fusion (L-PBF) of simple cubic lattice structures with foaming techniques. A combined process of foaming and electrodeposition has been also evaluated. The multifunctional scaffolds were characterized to evaluate their pore size, morphology, and distribution as well as their adhesion and behavior at the metal–polymer interface. Pull-out tests in dry and hydrated conditions were employed for the mechanical characterization. Additionally, a cytotoxicity assessment was performed to preliminarily evaluate their potential application in the biomedical field as load-bearing next-generation medical devices.

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On structure and mechanics of biomimetic meta-biomaterials fabricated via metal additive manufacturing

Cited by 21 publications

References 68 publications

Iodine-Loaded Calcium Titanate for Bone Repair with Sustainable Antibacterial Activity Prepared by Solution and Heat Treatment

Iodine-Loaded Calcium Titanate for Bone Repair with Sustainable Antibacterial Activity Prepared by Solution and Heat Treatment

Additively manufactured patient-specific prosthesis for tumor reconstruction: Design, process, and properties

Hybrid Ti6Al4V/Silk Fibroin Composite for Load-Bearing Implants: A Hierarchical Multifunctional Cellular Scaffold

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