Let K be a totally real number field and consider a Fermat-type equation Aa p + Bb q = Cc r over K. We call the triple of exponents (p, q, r) the signature of the equation. We prove various results concerning the solutions to the Fermat equation with signature (p, p, 2) and (p, p, 3) using a method involving modularity, level lowering and image of inertia comparison. These generalize and extend the recent work of Işik, Kara and Ozman. For example, consider K a totally real field of degree n with 2 ∤ h + K and 2 inert. Moreover, suppose there is a prime q ≥ 5 which totally ramifies in K and satisfies gcd(n, q − 1) = 1, then we know that the equation a p + b p = c 2 has no primitive, non-trivial solutions (a, b, c) ∈ O 3 K with 2|b for p sufficiently large.