We present a digital signal processing (DSP) scheme that performs hyperparameter tuning (HT) via Bayesian optimization (BO) to autonomously optimize memory tap distribution of Volterra series and adapt parameters used in the synthetization of a digital pre-distortion (DPD) filter for optical transmitters. Besides providing a time-efficient technique, this work demonstrates that the self-adaptation of DPD hyperparameters to correct the component-induced nonlinear distortions as different driver amplifier (DA) gains, symbol rates and modulation formats are used, leads to an improvement in transmitter performance. The scheme has been validated in backto-back (b2b) experiments using dual-polarization (DP) 64 and 256 quadrature amplitude modulation (QAM) formats, and symbol rates of 64 and 80 GBd. For DP-64QAM at 64 GBd, it isshown that the DPD scheme reduces the required optical signalto-noise ratio (OSNR) at a bit error ratio of 10 -2 by 0.9 dB and 0.6 dB with respect to linear DPD and a heuristic nonlinear DPD approach, respectively. Moreover, we show that the proposed approach also reduces filter complexity by 75% in conjunction with the use of memory polynomials (MP), while achieving a similar performance to Volterra pre-distortion filters.