On the antioxidant, neuroprotective and anti-inflammatory properties of S-allyl cysteine: An update

Colín-González, Ana Laura; Ali, Syed F.; Túnez, Isaac; Santamarı́a, Abel

doi:10.1016/j.neuint.2015.06.011

Cited by 86 publications

(58 citation statements)

References 82 publications

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“…Consistent with their findings it has been proposed that H 2 S acts as a pro‐inflammatory mediator of inflammation. H 2 S donors like diallyldisulfide (DADS), s‐allyl cysteine and diallyltrisulfide are shown to have anti‐cancer, anti‐inflammatory and neuroprotective effect . Therefore, an increasing interest in natural compounds that are capable of regulating H 2 S in inflammation is extended recently.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice

Velusamy

Tamizhselvi

2018

Journal of Pharmacy and Pharmacology

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Section: Discussionmentioning

confidence: 99%

Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice

Velusamy

Tamizhselvi

2018

Journal of Pharmacy and Pharmacology

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“…As autism often features oxidative stress and debilitating irritability [2,16], logic suggests that benfotiamine should be evaluated for efficacy in autism. S-allyl cysteine is a sulfur containing antioxidant compound in garlic with neuroprotective effects [51]. As autism often features high oxidative stress and clearly has neurologic References manifestations, S-allyl cysteine would also seem to be worthy of investigation in autism.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant sulfur compounds: potential therapies for autism?

Bittker¹

2016

J Autism

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Many of those with autism have biochemistry that is characterized by high levels of oxidative stress and low levels of sulfur antioxidants. Of the small set of compounds which have been shown to have some efficacy in double-blind trials in treating some aspects of autism, four are sulfur containing compounds with antioxidant properties. Specifically these four have been found to be efficacious with statistical significance in double-blind trials in autism: n-acetylcysteine, sulforaphane, l-carnitine, and a multivitamin containing methyl-sufonyl-methane and n-acetylcysteine. Each of these compounds has antioxidant properties, and there are other sulfur containing compounds with antioxidant properties which case studies suggest may have some efficacy in autism as well. The over-representation of sulfur containing antioxidants in the set of compounds that have been found to be therapeutic for autism as well as the indications of therapeutic potential of others, and the low levels of sulfur compounds and high oxidative stress that are often seen in autism biochemistry suggest that sulfur deficits are often fundamental to autism etiology, and sulfur containing antioxidants are worthy of additional study as a class of therapeutics for autism.

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“…In addition to SAC, aged garlic extracts contain allin, cycloallin, Smethyl cysteine, β-chlorogenin, and among others (ALLISON et al, 2006). Aged garlic extracts possess many pharmaco-therapeutic properties, including anti-oxidant, anti-allergic, anti-cancer, neuro-protective, and hepato-protective activities (COLIN-GONZALEZ et al, 2015;MORIHARA et al, 2006). SAC is the most abundant compound in aged garlic and has strong anti-oxidant activity (COLIN-GONZALEZ et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Aged garlic extracts possess many pharmaco-therapeutic properties, including anti-oxidant, anti-allergic, anti-cancer, neuro-protective, and hepato-protective activities (COLIN-GONZALEZ et al, 2015;MORIHARA et al, 2006). SAC is the most abundant compound in aged garlic and has strong anti-oxidant activity (COLIN-GONZALEZ et al, 2015). At the cellular level, reactive oxygen species (ROS), including superoxide radical and hydrogen peroxide (H 2 O 2 ), are reduced by SAC treatment LAU, 2001;MALDONADO et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Supplementation of S-allyl cysteine improves health span in Caenorhabditis elegans

Kim¹

2017

Biosci. J.

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Previous studies show that nutritional interventions with anti-oxidants have various healthpromoting effects in several model organisms. Here, we examine the effects of S-allyl cysteine on resistance to environmental stressors and age-related physiological changes using C. elegans as a model system. S-allyl cysteine is a modified amino acid found in aged garlic extracts and known to have strong anti-oxidant activity. The survival of worms under oxidative-stress conditions significantly increased with supplementation of S-allyl cysteine. In addition, pretreatment of S-allyl cysteine significantly increased resistance to both heat stress and ultraviolet irradiation. However, lifespan was not affected by S-allyl cysteine treatment. We also examined the effect of S-allyl cysteine on motility of C. elegans and found that S-allyl cysteine can retard the age-related decline of muscle tissue locomotive activity. S-allyl cysteine also significantly suppressed amyloid β-induced paralysis in Alzheimer's disease model animals. Taken together, our study indicates that dietary supplementation of S-allyl cysteine can improve health span and suggests that S-allyl cysteine can be used to develop novel health-promoting pharmaceuticals.

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On the antioxidant, neuroprotective and anti-inflammatory properties of S-allyl cysteine: An update

Cited by 86 publications

References 82 publications

Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice

Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice

Antioxidant sulfur compounds: potential therapies for autism?

Supplementation of S-allyl cysteine improves health span in Caenorhabditis elegans

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