We show a rigidity theorem for the Seiberg-Witten invariants mod 2 for families of spin 4-manifolds. We also give a family version of 10/8-type inequality using this rigidity theorem. As applications, we shall give a new series of non-smoothable topological actions on some 4-manifolds, and also prove the existence of a non-smoothable topological family of 4-manifolds whose fiber, base space, and total space are smoothable as manifolds. As a consequence, it follows that the inclusion map Diff(M ) ֒→ Homeo(M ) is not a weak homotopy equivalence for a smooth 4-manifold M which is homeomorphic to K3#nS 2 × S 2 with 0 ≤ n ≤ 3.