In this paper we investigate the center problem for the discontinuous piecewise smooth quasi-homogeneous but non-homogeneous polynomial differential systems. First, we provide sufficient and necessary conditions for the existence of a center in the discontinuous piecewise smooth quasihomogeneous polynomial differential systems. Moreover, these centers are global, and the period function of their periodic orbits is monotonic. Second, we characterize the centers of the discontinuous piecewise smooth quasihomogeneous cubic and quartic polynomial differential systems.