On the Classification of the Phenomena of Hypersensitiveness

Abstract

I. By Arthur F. Coca. Robert Doerr was the first to recognize the need of a classification of the phenomena of hypersensitiveness. In attempting such a classification Doerr (7), unfortunately chose as the main heading the term Allergie (allergy) which had been introduced by von Pirquet. This choice was particularly unhappy because Doerr felt obliged in using it to observe with some strictness the etymological significance of the term (altered reactivity). The result of this observance was the inclusion in Doerr's category of allergies of phenomena of such different nature as to make their association valueless if not positively confusing. There seems, for example, to be no advantage in associating in one category two so widely different phenomena as the well known morphine tolerance and morphine idiosyncrasy. Doerr's subdivision of “allergic” phenomena into those exhibited to non-antigenic substances and those exhibited to antigenic substances is also inadvisable because such subdivision necessitates a confusing separation of identical conditions of hypersensitiveness in human beings, merely in accordance with the presence or absence of antigenic property in the exciting agent.

How an Immune-Factor-Based Formulation of Micro-Immunotherapy Could Interfere with the Physiological Processes Involved in the Atopic March

“…Allergic diseases have become an increasing problem in civilization in recent decades, as allergic symptoms currently affect 150 million Europeans, according to the European academy of allergology and clinical immunology (EAACI) [ 1 ]. Coca and Cooke were the first to introduce the term “atopy” and classify the phenomenon of hypersensitiveness in 1923 [ 2 ]. Atopy defines the inappropriate immune reaction to allergic stimuli, mediated by high immunoglobulin (Ig) E levels, ultimately leading to clinical manifestations at various localizations within the body.…”

Atopische Dermatitis – Perspektiven und unerfüllte medizinische Bedarfe

“…atopic eczema, contact allergic eczema, irritative-toxic eczema, JAK inhibitors Der medizinische Begriff "Atopie" wurde vor genau 100 Jahren geprägt, als Arthur Coca und Robert Cooke im Jahr 1923 ihre Arbeit "On the classification of the phenomena of hypersensitiveness" in der damals wie heute renommierten Fachzeitschrift Journal of Immunology publizierten. 1 Schon bei Erscheinen dieser Arbeit gab es zahlreiche wissenschaftliche Diskussionen und Kontroversen um die Präzision und die Abgrenzung von "Atopie" insbesondere zur "Anaphylaxie" und "Allergie". 2 Auch 100 Jahre später ist "Atopie" ein schwieriger Begriff, da zahlreiche Krankheitsbilder und pathophysiologische Charakteristika hierunter subsummiert werden und sich die Trennschärfe dieses Begriffs gerade Medizinstudierenden nur schwer erschließt.…”

“…Der medizinische Begriff „Atopie“ wurde vor genau 100 Jahren geprägt, als Arthur Coca und Robert Cooke im Jahr 1923 ihre Arbeit „On the classification of the phenomena of hypersensitiveness“ in der damals wie heute renommierten Fachzeitschrift Journal of Immunology publizierten 1 . Schon bei Erscheinen dieser Arbeit gab es zahlreiche wissenschaftliche Diskussionen und Kontroversen um die Präzision und die Abgrenzung von „Atopie“ insbesondere zur „Anaphylaxie“ und „Allergie“ 2 .…”

Atopic dermatitis – Perspectives and unmet medical needs

“…The medical term "atopy" was coined exactly 100 years ago, when Arthur Coca and Robert Cooke published their paper "On the classification of the phenomena of hypersensitivity" in 1923 in the renowned "Journal of Immunology". 1 Already at the time of publication there were numerous scientific discussions and controversies about the precision and the distinction of the term "atopy" in particular from "anaphylaxis" and "allergy". 2 Even 100 years later, "atopy" is a challenging term, as numerous clinical pictures and pathophysiological characteristics are subsumed under it, and the discriminatory power of this term is difficult to understand, especially for medical students.…”

“…The medical term “atopy” was coined exactly 100 years ago, when Arthur Coca and Robert Cooke published their paper “On the classification of the phenomena of hypersensitivity” in 1923 in the renowned “Journal of Immunology” 1 . Already at the time of publication there were numerous scientific discussions and controversies about the precision and the distinction of the term “atopy” in particular from “anaphylaxis” and “allergy” 2 .…”