On the design, functions, and biomedical applications of high-throughput dielectrophoretic micro-/nanoplatforms: a review

Li, Yalin; Wang, Yan; Wan, Keming; Wu, Ming‐Xue; Guo, Lei; Liu, Xiaomin; Wei, Gang

doi:10.1039/d0nr08892g

Cited by 31 publications

(18 citation statements)

References 160 publications

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“…This method generates motion of dielectric particles such as polymer beads in a non-uniform electric field. The particle will be attracted to either the positive or negative electrode based on the particle’s permittivity and will be held by the electrode until further interrogation [ 4 ]. Magnetic trapping works similarly to electrical but is implemented instead with a magnetic field.…”

Section: Introductionmentioning

confidence: 99%

Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel

et al. 2022

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We demonstrate an optofluidic device which utilizes the optical scattering and gradient forces for particle trapping in microchannels featuring 300 nm thick membranes. On-chip waveguides are used to direct light into microfluidic trapping channels. Radiation pressure is used to push particles into a protrusion cavity, isolating the particles from liquid flow. Two different designs are presented: the first exclusively uses the optical scattering force for particle manipulation, and the second uses both scattering and gradient forces. Trapping performance is modeled for both cases. The first design, referred to as the orthogonal force design, is shown to have a 80% capture efficiency under typical operating conditions. The second design, referred to as the gradient force design, is shown to have 98% efficiency under the same conditions.

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Section: Introductionmentioning

confidence: 99%

Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel

et al. 2022

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“…The high throughput of DLD makes up for the limitations of DEP, improving the processing capacity while ensuring a high separation efficiency between breast cancer cells and leukocytes. While the use of 3D microelectrodes and/or the integration of DEP with other technologies further improved the throughput of the DEP system and demonstrated its potential for clinical application in cell classification, the throughput has not yet reached the threshold of some clinical sample analysis, e.g., recovery of CTCs from peripheral blood cells [20].…”

Section: Introductionmentioning

confidence: 99%

Rational Design and Numerical Analysis of a Hybrid Floating cIDE Separator for Continuous Dielectrophoretic Separation of Microparticles at High Throughput

Wang

Pesch

et al. 2022

Micromachines

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Dielectrophoresis (DEP) enables continuous and label-free separation of (bio)microparticles with high sensitivity and selectivity, whereas the low throughput issue greatly confines its clinical application. Herein, we report a novel design of the DEP separator embedded with cylindrical interdigitated electrodes that incorporate hybrid floating electrode layout for (bio)microparticle separation at favorable throughput. To better predict microparticle trajectory in the scaled-up DEP platform, a theoretical model based on coupling of electrostatic, fluid and temperature fields is established, in which the effects of Joule heating-induced electrothermal and buoyancy flows on particles are considered. Size-based fractionation of polystyrene microspheres and dielectric properties-based isolation of MDA-MB-231 from blood cells are numerically realized, respectively, by the proposed separator with sample throughputs up to 2.6 mL/min. Notably, the induced flows can promote DEP discrimination of heterogeneous cells. This work provides a reference on tailoring design of enlarged DEP platforms for highly efficient separation of (bio)samples at high throughput.

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“…26 The acoustophoresis techniques are hindered by the short-term cell viability within the radiation force field. 13 Dielectrophoresis (DEP) force is capable of highthroughput manipulation of cells by applying a non-uniform electric field on cells and thus enables a label-free separation method to purify cells, 27,28 such as cancerous cells 29 and pluripotent embryonic stem cells. 30 Nevertheless, the DEP method lacks flexibility in dynamic and reconfigurable manipulation due to its predesigned physical electrodes.…”

Section: Introductionmentioning

confidence: 99%

Label-free purification and characterization of optogenetically engineered cells using optically-induced dielectrophoresis

Yang

Zhang

et al. 2022

Lab Chip

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On the design, functions, and biomedical applications of high-throughput dielectrophoretic micro-/nanoplatforms: a review

Abstract: As an efficient, rapid and label-free micro-/nanoparticle separation technique, dielectrophoresis (DEP) has attracted widespread attention in recent years, especially in the field of biomedicine, which exhibits huge potential in biomedical...

Cited by 31 publications

References 160 publications

Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel

Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel

Rational Design and Numerical Analysis of a Hybrid Floating cIDE Separator for Continuous Dielectrophoretic Separation of Microparticles at High Throughput

Label-free purification and characterization of optogenetically engineered cells using optically-induced dielectrophoresis

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