On the Development of a Novel Contrast Pulse Sequence for Polymer-Shelled Microbubbles

Chen, Hongjian; Evangelou, Dimitrios; Loskutova, Ksenia; Ghorbani, Morteza; Grishenkov, Dmitry

doi:10.1109/tuffc.2020.3041206

Cited by 7 publications

(6 citation statements)

References 45 publications

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“…Two regions of interest (ROI) were selected in each B-mode image: (1) the ROI located in the flow channel region containing the microbubble suspension, and (2) the ROI outside the flow channel. Subsequently, the contrast-to-noise ratio (CNR) and contrast-to-tissue (phantom) ratio (CTR) were calculated for three ROI pairs in each B-mode frame to assess the imaging quality , (Figure S4). The expressions for CNR and CTR calculation are as follows: …”

Section: Methodsmentioning

confidence: 99%

Combining Ultrasound and Capillary-Embedded T-Junction Microfluidic Devices to Scale Up the Production of Narrow-Sized Microbubbles through Acoustic Fragmentation

et al. 2022

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Microbubbles are tiny gas-filled bubbles that have a variety of applications in ultrasound imaging and therapeutic drug delivery. Microbubbles can be synthesized using a number of techniques including sonication, amalgamation, and saline shaking. These approaches can produce highly concentrated microbubble suspensions but offer minimal control over the size and polydispersity of the microbubbles. One of the simplest and effective methods for producing monodisperse microbubbles is capillary-embedded T-junction microfluidic devices, which offer great control over the microbubble size. However, lower production rates (∼200 bubbles/s) and large microbubble sizes (∼300 μm) limit the applicability of such devices for biomedical applications. To overcome the limitations of these technologies, we demonstrate in this work an alternative approach to combine a capillary-embedded T-junction device with ultrasound to enhance the generation of narrow-sized microbubbles in aqueous suspensions. Two T-junction microfluidic devices were connected in parallel and combined with an ultrasonic horn to produce lipid-coated SF6 core microbubbles in the size range of 1–8 μm. The rate of microbubble production was found to increase from 180 microbubbles/s in the absence of ultrasound to (6.5 ± 1.2) × 106 bubble/s in the presence of ultrasound (100% ultrasound amplitude). When stored in a closed environment, the microbubbles were observed to be stable for up to 30 days, with the concentration of the microbubble suspension decreasing from ∼2.81 × 109/mL to ∼2.3 × 106/mL and the size changing from 1.73 ± 0.2 to 1.45 ± 0.3 μm at the end of 30 days. The acoustic response of these microbubbles was examined using broadband attenuation spectroscopy, and flow phantom imaging was performed to determine the ability of these microbubble suspensions to enhance the contrast relative to the surrounding tissue. Overall, this approach of coupling ultrasound with microfluidic parallelization enabled the continuous production of stable microbubbles at high production rates and low polydispersity using simple T-junction devices.

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Section: Methodsmentioning

confidence: 99%

Combining Ultrasound and Capillary-Embedded T-Junction Microfluidic Devices to Scale Up the Production of Narrow-Sized Microbubbles through Acoustic Fragmentation

et al. 2022

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“…Therefore, the linear part of the signal from the tissue background is suppressed so as to increase the nonlinear signals from the ultrasound contrast agents injected into the bloodstream. 33 An overview of imaging techniques based on the nonlinearity of ultrasound contrast agents is shown in Figure 3.…”

Section: ■ Advanced Detection Techniquesmentioning

confidence: 99%

“…After emitting acoustic waves from the ultrasound transducer, the ultrasound contrast agents will be hit and backscattered with a nonlinear signal, whereas tissues are more likely to send back linear signals. Therefore, the linear part of the signal from the tissue background is suppressed so as to increase the nonlinear signals from the ultrasound contrast agents injected into the bloodstream . An overview of imaging techniques based on the nonlinearity of ultrasound contrast agents is shown in Figure .…”

Section: Advanced Detection Techniquesmentioning

confidence: 99%

Ultrasound Molecular Imaging and Its Applications in Cancer Diagnosis and Therapy

Zhang

Sun

et al. 2022

ACS Sens.

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Ultrasound imaging is regarded as a highly sensitive imaging modality used in routine clinical examinations. Over the last several decades, ultrasound contrast agents have been widely applied in ultrasound molecular cancer imaging to improve the detection, characterization, and quantification of tumors. To date, a few new potential preclinical and clinical applications regarding ultrasound molecular cancer imaging are being investigated. This review presents an overview of the various kinds of ultrasound contrast agents employed in ultrasound molecular imaging and advanced imaging techniques using these contrast agents. Additionally, we discuss the recent enormous development of ultrasound contrast agents in the relevant preclinical and clinical applications, highlight the recent challenges which need to be overcome to accelerate the clinical translation, and discuss the future perspective of ultrasound molecular cancer imaging using various contrast agents. As a highly promising and valuable tumor-specific imaging technique, it is believed that ultrasound molecular imaging will pave an accurate and efficient way for cancer diagnosis.

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“…The TIA is followed by a second-order high-pass filter (HPF) and a second-order low-pass filter (LPF). Both HPF and LPF can be programmed independently by an 8-bit control code so that the BPF can be programmed to a full bandwidth (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) or it can be restricted at a harmonic band. The LPF also works as an antialiasing filter before the ADC.…”

Section: Afe and Adcmentioning

confidence: 99%

“…As an alternative, pulse inversion (PI) techniques [9], [10] that are well known in the signal processing domain can overcome this issue by combining two acquisitions for one image. More recently, a new approach, combining different harmonic components with PI based on digital BPFs, shows further contrast improvements in CEUS [11].…”

Section: Introductionmentioning

confidence: 99%

A Prototype System With Custom-Designed RX ICs for Contrast-Enhanced Ultrasound Imaging

Zhou

Chen

Pollet

et al. 2022

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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On the Development of a Novel Contrast Pulse Sequence for Polymer-Shelled Microbubbles

Cited by 7 publications

References 45 publications

Combining Ultrasound and Capillary-Embedded T-Junction Microfluidic Devices to Scale Up the Production of Narrow-Sized Microbubbles through Acoustic Fragmentation

Combining Ultrasound and Capillary-Embedded T-Junction Microfluidic Devices to Scale Up the Production of Narrow-Sized Microbubbles through Acoustic Fragmentation

Ultrasound Molecular Imaging and Its Applications in Cancer Diagnosis and Therapy

A Prototype System With Custom-Designed RX ICs for Contrast-Enhanced Ultrasound Imaging

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