On the diabetic menu: Zebrafish as a model for pancreas development and function

Kinkel, Mary D.; Prince, Victoria

doi:10.1002/bies.200800123

Cited by 130 publications

(111 citation statements)

References 117 publications

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“…The pancreas in the zebrafish contains exocrine and endocrine parts, similar to those found in mammals. Several genes have been shown to influence the development of β-cells in the zebrafish (Kinkel et al 2009) and again this information has been used to produce lines of transgenic fish, useful in diabetes research. Beta-cells can be visualized in Danio rerio line, where the fluorescent reporter is placed under the control of the insulin promoter (Seth et al 2013).…”

Section: Metabolic Diseasesmentioning

confidence: 99%

Zebrafish: an animal model for research in veterinary medicine

Nowik¹,

Podlasz²,

Jakimiuk³

et al. 2015

Polish Journal of Veterinary Sciences

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The zebrafish (Danio rerio) has become known as an excellent model organism for studies of vertebrate biology, vertebrate genetics, embryonal development, diseases and drug screening. Nevertheless, there is still lack of detailed reports about usage of the zebrafish as a model in veterinary medicine. Comparing to other vertebrates, they can lay hundreds of eggs at weekly intervals, externally fertilized zebrafish embryos are accessible to observation and manipulation at all stages of their development, which makes possible to simplify the research techniques such as fate mapping, fluorescent tracer time-lapse lineage analysis and single cell transplantation. Although zebrafish are only 2.5 cm long, they are easy to maintain. Intraperitoneal and intracerebroventricular injections, blood sampling and measurement of food intake are possible to be carry out in adult zebrafish. Danio rerio is a useful animal model for neurobiology, developmental biology, drug research, virology, microbiology and genetics. A lot of diseases, for which the zebrafish is a perfect model organism, affect aquatic animals. For a part of them, like those caused by Mycobacterium marinum or Pseudoloma neutrophila, Danio rerio is a natural host, but the zebrafish is also susceptible to the most of fish diseases including Itch, Spring viraemia of carp and Infectious spleen and kidney necrosis. The zebrafish is commonly used in research of bacterial virulence. The zebrafish embryo allows for rapid, non-invasive and real time analysis of bacterial infections in a vertebrate host. Plenty of common pathogens can be examined using zebrafish model: Streptococcus iniae, Vibrio anguillarum or Listeria monocytogenes. The steps are taken to use the zebrafish also in fungal research, especially that dealing with Candida albicans and Cryptococcus neoformans. Although, the zebrafish is used commonly as an animal model to study diseases caused by external agents, it is also useful in studies of metabolic disorders including fatty liver disease and diabetes. The zebrafish is also a valuable tool as a model in behavioral studies connected with feeding, predator evasion, habituation and memory or lateralized control of behavior. The aim of the present article is to familiarize the reader with the possibilities of Danio rerio as an experimental model for veterinary medicine.

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Section: Metabolic Diseasesmentioning

confidence: 99%

Zebrafish: an animal model for research in veterinary medicine

Nowik¹,

Podlasz²,

Jakimiuk³

et al. 2015

Polish Journal of Veterinary Sciences

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“…Cyp26 RA-degrading enzymes and Hh signaling have been implicated to play a role in blocking RA-mediated pancreas specification in the anterior endoderm, 33,48 while in the posterior endoderm it is blocked by the Cdx4 transcription factor. 49 As gastrulation proceeds, convergent extension (CE) movements carry cells of all three germ layers toward the dorsal midline 50 ( Fig. 1B), a process mediated in the endoderm by Sdf1/ Cxcr4 chemokine signaling 51,52 and noncanonical Wnt signaling.…”

Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

“…A number of key transcription factors constitute a core program of endocrine development and function, since they are expressed in all endocrine precursor cells as well as in mature islets and are required for the development of many if not all islet cell types. 50,55 Interestingly, most of these transcription factors are involved in early central nervous system development as well. One of the earliest regulators of endocrine pancreas specification is neurod, which is first detected in endocrine precursors at about 14 hpf (10s) and later becomes restricted to mature β cells.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

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Endocrine pancreas development in zebrafish

Tehrani¹,

Lin²

2011

Cell Cycle

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“…2). Zebrafish development is rapid; by the end of the first day of development the dorsal pancreatic bud that gives rise to the primary islet is already morphologically apparent.…”

Section: Introductionmentioning

confidence: 99%

Mnx1

Dalgin

Prince²

2012

Islets

Self Cite

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A full understanding of embryonic endocrine pancreas development will be key to the establishment of islet replacement strategies. In particular, it is important to identify molecular pathways that establish the correct balance of specific endocrine pancreatic islet cell types. Recently, our work in the zebrafish has revealed that the correct ratio of α and β cell fates depends on the homeodomain transcription factor Mnx1 (Hb9); in the absence of functional Mnx1, β cell precursors give rise to α cells. 1 Our study suggests that mnx1 may function in β cell precursors to suppress the α cell fate. Here we consider how Mnx1 may interact with other endocrine-specific transcription factors to specify β cells. Our work emphasizes the vital importance of Mnx1 for β cell development, and suggests that identifying Mnx1 transcriptional targets in β cell precursors may provide important new information of direct relevance to stem cell-based protocols to cure diabetes.

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On the diabetic menu: Zebrafish as a model for pancreas development and function

Cited by 130 publications

References 117 publications

Zebrafish: an animal model for research in veterinary medicine

Zebrafish: an animal model for research in veterinary medicine

Endocrine pancreas development in zebrafish

Mnx1

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