a b s t r a c tCombustion modes in locally stratified dual-fuel (DF) mixtures are numerically investigated for methanol/n-dodecane blends under engine-relevant pressures. In the studied constant-volume numerical setup, methanol acts as a background low-reactivity fuel (LRF) while n-dodecane serves as high-reactivity fuel (HRF), controlling local ignition delay time. The spatial distribution of n-dodecane is modeled as a sinusoidal function parametrized by stratification amplitude ( Y ) and wavelength (0.01 mm <λ< 15 mm). In contrast, methanol is assumed to be fully premixed with air at equivalence ratio 0.8. First, onedimensional setup is investigated by hundreds of chemical kinetics simulations in ( Y , λ) parameter space. Further, the concepts by Sankaran et al. (2005, Proceedings of the Combustion Institute ) and Zeldovich (1980, Combustion and Flame ) on ignition front propagation speed are applied to develop a theoretical analysis of the time-dependent diffusion-reaction problem. The theoretical analysis predicts two combustion modes, (1) spontaneous ignition and (2) deflagrative propagation, and leads to an analytical expression for the border curve called β-curve herein. One-dimensional chemical kinetics simulations confirm the presence of two combustion modes in ( Y , λ) parameter space while the β-curve explains consistently the position of phase border observed in the simulations. Finally, the role of convective mixing is incorporated to the theoretical expression for the β-curve. The effect of convection on combustion modeis assessed by carrying out two-dimensional fully-resolved simulations with different turbulence levels. Two-dimensional numerical simulation results give evidence on combustion mode switching, which is consistent with predictions of the modified β-curve for turbulent cases. The practical output of the paper is the β-curve which is proposed as a predictive tool to estimate combustion modes for various fuels or fuel combinations.