On the Enantioselective Phosphoric-Acid-Catalyzed Hantzsch Synthesis of Polyhydroquinolines

Abstract

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Silica sulfuric acid coated on SnFe2O4MNPs: synthesis, characterization and catalytic applications in the synthesis of polyhydroquinolines

“…of dimedone is heated with aldehyde derivatives in the presence of ethyl acetoacetate and an ammonia source. [1][2][3] In this sense, a multi-step sequence ensues, a water molecule is lost and the target sixmembered nitrogen-containing scaffold is formed. 4,5 It possesses a chiral center at the phenyl-substituted carbon.…”

Synthesis of Quinoline and Polyhydroquinoline Derivatives Using Phloroglucinol Cored Amino Functionalized Dendritic Polymer as Catalyst

“…These chemicals have been shown to have a variety of medicinal functions, [30–34] including neuroprotectant, [35] platelet anti‐aggregatory action, [36–38] cerebral antischemic activity [39] in the treatment of Alzheimer's disease, [40] and as chemosensitizer in tumour therapy [41] . These examples show the extraordinary potential of dihydropyridine (polyhydroquinoline) derivatives as a source of promising therapeutic candidates [42–44] . In addition, the oxidation of these compounds to pyridines has been thoroughly investigated.…”

“…[41] These examples show the extraordinary potential of dihydropyridine (polyhydroquinoline) derivatives as a source of promising therapeutic candidates. [42][43][44] In addition, the oxidation of these compounds to pyridines has been thoroughly investigated. As a result, the synthesis of this heterocyclic nucleus is crucial.…”