On the erythron response to inflammation and its mechanisms

Abstract

Using the mouse model of acute infectious peritonitis caused by Escherichia coli, it isshown that the development of inflammation is accompanied by increases in the number of erythrokaryocytes, erythroid colony-forming units, and erythroid hematopoietic islets in the bone marrow and by rises in the activities of supernatants of cultured stimulated adherent and nonadherent myelokaryocytes and of peripheral blood. The results of this study indicate that a characteristic feature of acute inflammation is strong activation of erythropoiesis with the development of hyperplasia of the erythroid marrow. Key Words: inflammation; erythropoiesisThe mechanisms underlying the regulation of erythropoiesis in inflammation have been studied inadequately, and the available information about quantitative changes in the erythron during inflammatory processes is scanty and contradictory. There are reports of anemia with a fall in the number of erythroid cells in the bone marrow occurring as early as 24 h after the experimental induction of acute inflammation and peaking on days 6-9 [1,2,8], and erythrocytosis has been found to develop at the same times [6].The present experiment was undertaken to investigate the response of the erythron to acute inflammation and the mechanisms of this response. MATERIALS AND METHODSThe experiment was carried out on 102 male CBA mice weighing 18-20 g. The model of inflammation was infectious peritonitis caused by Escherichia coli strain ATCC 25922 inoculated intraperitoneaUy in

Role of mast cells in regulation of erythropoiesis during inflammation

“…It was also shown that inflammation characterized by marked stimulation of erythropoiesis and on days 6-9 of inflammation by hyperplasia of erythron in_ the bone marrow due to activation of proliferation and differentiation of committed erythropoiesis precursors, hemopoiesis-inducing microenvironment (HIM) of the bone marrow, and the erythropoietin system [2].…”

Dynamic theory of hemopoiesis regulation

“…For instance, immobilization stress equally stimulates erythro-and granulomonocytopoiesis [99], while inflammation affects primarily white blood cells [59], which can be explained by the key role of neutrophils, mast cells, and monocytes in the development and solution of inflammation [22,57,58,60,78,103]. However, similarly to other stress reactions, acute inflammation is also accompanied by stimulation of erythropoiesis due to functional activation of HIM erythron [23,59,79]. On the contrary, massive blood loss is accompanied by stimulation of the erythron due to circulatory and hemic hypoxia [16,101, while stimulation of granulomonocytopoiesis is less pronounced.…”