G-Brownian motion has potential applications in uncertainty problems and risk measures, which has attracted the attention of many scholars. This study investigates the almost sure exponential stability of nonlinear stochastic delay hybrid systems driven by G-Brownian motion. Due to the non-linearity of G-expectation and distribution uncertainty of G-Brownian motion, it is difficult to study this issue. Firstly, the existence of the global unique solution is derived under the linear growth condition and local Lipschitz condition. Secondly, the almost sure exponential stability of the system is analyzed by applying the G-Lyapunov function and G-Itô formula. Finally, an example is introduced to illustrate the stability. The conclusions of this paper can be applied to the stability and risk management of uncertain financial markets.