On the Genealogy of Tissue Engineering and Regenerative Medicine

Abstract

In this article, we identify and discuss a timeline of historical events and scientific breakthroughs that shaped the principles of tissue engineering and regenerative medicine (TERM). We explore the origins of TERM concepts in myths, their application in the ancient era, their resurgence during Enlightenment, and, finally, their systematic codification into an emerging scientific and technological framework in recent past. The development of computational/mathematical approaches in TERM is also briefly discussed.

Synergistic activity of polarised osteoblasts inside condensations cause their differentiation

“…Besides aiding our fundamental understanding of a significant biological event, results from this investigation display how computations can serve as efficacious supplements to experiments. As the philosophy behind the use of computational strategies is to condense the lab into the computer, and the experiment into the code 35 , we also tested the model’s sensitivity to stochastic variables within the code as well as result reproducibility across various computer systems. This was achieved by running models (employing the four hypotheses) on separate workstations.…”

Cross-border assistance in Advanced Therapies: analysis of a new reality in Health

“…En primer lugar, porque aún reconociendo la dificultad técnica y normativa inherente a la construcción de tejidos, el fin de esta disciplina se proyecta directamente a la terapéutica, así "no alcanza a mi juicio [la ingeniería tisular] toda su dimensión y trascendencia hasta que no se traslada a la clínica con las dificultades y los exigentes requisitos que la actual normativa demanda" (18). Y en segundo lugar, porque se estudia incluida en una dimensión más amplia, que es aquella que pretende comprender la constitución del cuerpo humano bajo un nuevo paradigma: el paradigma constructivo (19), (20).…”

“…(21) y con frecuencia provienen de fuentes opacas (22). Además, los países se han especializado en determinadas prestaciones: Singapur es conocido por las prestaciones de alta tecnología, Tailandia en cirugía cardíaca, ortopédica e intervenciones de cambio de sexo, el Este de Europa en odontología y España para tratamientos de fertilidad (20). No obstante, puede afirmarse que aquí son tres los actores involucrados: 1) usuario; 2) profesional del área de la salud; y 3) figura intermediaria o tercera empresa (agencias de turismo, compañías o brókers).…”

The Progression of Regenerative Medicine and its Impact on Therapy Translation

“…Although RM may have seemed novel, the principles of regeneration are as old as humanity and are found in its many cultures. 8 A common example used is the tale of Prometheus that appeared in 8th century BCE. Prometheus, an immortal Titan in Greek mythology, stole fire and gave it to humanity for them to use, defying the gods in consequence.…”