This paper investigates hybrid synchronization of the uncertain generalized Lorenz system. Several useful criteria are given for synchronization of two generalized Lorenz systems, and the adaptive control law and the parameter update law are used. In comparison with those of existing synchronization methods, hybrid synchronization includes full-order synchronization, reduced-order synchronization, and modified projective synchronization. What is more, control of the stability point, complete synchronization, and antisynchronization can coexist in the same system. Numerical simulations show the effectiveness of this method in a class of chaotic systems.