On the genus Gnathostoma and human gnathostomiasis, with special reference to Japan

Miyazaki, I.

doi:10.1016/0014-4894(60)90040-0

Cited by 109 publications

(73 citation statements)

References 23 publications

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“…Since it was ®rst discovered in the stomach wall of a tiger that died in the London Zoological Gardens in 1836 [41], various species of Gnathostoma have been identi®ed throughout the world [42]. However, most endemic foci have been identi®ed in Asia [43].…”

Section: Gnathostomiasismentioning

confidence: 99%

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Emerging helminth zoonoses

McCarthy

Moore

2000

International Journal for Parasitology

209

133

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Section: Gnathostomiasismentioning

confidence: 99%

“…Although Mexico and countries in Asia have to date reported the largest number of cases of gnathostomiasis, endemic foci have been identi®ed on nearly every continent [42]. Therefore, one would expect that human infections may occur globally, but have not been recognized or reported.…”

Section: Gnathostomiasismentioning

confidence: 99%

Emerging helminth zoonoses

McCarthy

Moore

2000

International Journal for Parasitology

209

133

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“…In Gnathostoma nipponicum is a common nematode found in esophageal tumors of weasels, and is widely distributed in Japan [2, 5-7, 16, 23]. Recently, G. nipponicum has been found as a cause of human gnathostomiasis [1,3,22,24], as in the case of G. spinigerum [12], G. doloresi [14], and G. hispidum [10]. In the human cases, some freshwater fish were suspected of being the source of infection.…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, it was proved that four fish species of Gobiidae, Odontobius obscura obscura, Glossogobius olivaceus, Acanthogobius hasta, and A. flavimanus, were susceptible to G. spinigerum larvae infection [8,12,13]. This suggested the possibility of G. nipponicum larvae infection in Gobiidae fish in nature.…”

Section: Methodsmentioning

confidence: 99%

Survey for Gnathostoma nipponicum Larvae in Gobiid Freshwater Fish and Infectivity of the Larvae to a Gobiid Fish (Chaenogobius urotaenia).

Oyamada

Kudo

Yoshikawa

et al. 1997

The Journal of Veterinary Medical Science

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ABSTRACT. From June 1993 to November 1996, a total of 977 gobiid fish consisting of three species (Tridentiger brevispinis, Chaenogobius urotaenia, and Rhinogobius brunneus) collected from eastern Aomori Prefecture, were examined for Gnathostoma nipponicum larvae infection. Only one species, C. urotaenia was infected with advanced third-stage larvae (AdL3), and a total of 22 larvae were recovered from 17 (3.4%) of 500 fish. The infected fish were larger than 12 cm in body length and collected in the May-June and SeptemberNovember seasons. Experimental studies confirmed that C. urotaenia was susceptible to both the early third-stage larvae (EaL3) obtained from Eucyclops serrulatus and AdL3 from Misgurnus anguillicaudatus. Eight of 10 C. urotaenia inoculated orally with 10 EaL3 were positive, and 36 AdL3 were recovered from them (recovery rate: 36.0%) at 30 days postinoculation (PI). All 10 C. urotaenia inoculated with 10 AdL3 were also positive, and a total of 63 AdL3 were recovered (recovery rate: 63.0%) at 10 days PI. The main location of the larvae was the body muscles of the fish. No morphological alterations or death of the larvae were observed in this study. From these results, it seems that the C. urotaenia has characteristics suitable to be the host to the larvae and they may serve as the second intermediate and paratenic host in the natural life cycle of this nematode. -KEY WORDS: advanced third-stage larvae, Chaenogobius urotaenia, Gnathostoma nipponicum, gobiid fish, life cycle.

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“…The interaction mechanisms between the ADVL3 of G. binucleatum and the host have not yet been determined clearly; hence, little is known of the pathogenesis of this nematode. However, Miyazaki (Miyazaki, 1960) has described that the damage caused by parasites of the genus Gnathostoma may be due to a combination of factors, including the mechanical effects of migration by the parasite, the elimination of toxic substances, proteolytic enzymes, and the host's inflammatory reaction. It has been reported that when the larvae are ingested by a host, they lose their cystic envelope in the stomach, perforate the stomach wall, and then migrate to the liver.…”

Section: Introductionmentioning

confidence: 99%

Proteases secreted by Gnathostoma binucleatum degrade fibronectin and antibodies from mammals

Vibanco-Pérez¹,

Durán‐Avelar²,

Zambrano‐Zaragoza³

et al. 2015

Helminthologia

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SummaryGnathostomiasis is a prevalent zoonosis in humans in some regions of the world. The genus Gnathostoma is considered an accidental parasite for humans; G. binucleatum is the endemic species in Nayarit, Mexico. This work was designed to determine the proteolytic activity of the excretory-secretory products (ESP) of advanced third-stage larvae (ADVL3) of Gnathostoma binucleatum against human fibronectin and antibodies from human and sheep. Our findings showed protease activity against human fibronectin as well as sheep and human gamma globulins of the ESP at molecular weights of 80 and 56 kDa. The proteases found in the ESP of G. binucleatum are thus candidate molecules for consideration as pathogenic elements, owing to the fact that they destroy proteins of the host tissue, which probably allows them to migrate through those tissues and degrade molecules involved in the humoral immune response.

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On the genus Gnathostoma and human gnathostomiasis, with special reference to Japan

Cited by 109 publications

References 23 publications

Emerging helminth zoonoses

Emerging helminth zoonoses

Survey for Gnathostoma nipponicum Larvae in Gobiid Freshwater Fish and Infectivity of the Larvae to a Gobiid Fish (Chaenogobius urotaenia).

Proteases secreted by Gnathostoma binucleatum degrade fibronectin and antibodies from mammals

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