On the Influence of Geometric Parameters of a Combined Orifice Valve on the Attainable Mean Droplet Diameter during High-Pressure Homogenization

A surprisingly large proportion of new drug candidates emerging from drug discovery programmes are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. These so-called 'brickdust' candidates can now be rescued by formulating them into crystalline nanosuspensions. In the process of overcoming issues involving solubility, additional pharmacokinetic benefits of the drugs so formulated have come to be appreciated. As such, insolubility issues of the past have provoked a paradigm change, which now offers novel solutions for innovative drugs of the future.

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Nanosuspensions in drug delivery

Rabinow

2004

Nat Rev Drug Discov

1,349

759

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Vitamin E Nanoparticle for Beverage Applications

Chen¹,

Wagner²

2004

Chemical Engineering Research and Design

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On the Influence of Geometric Parameters of a Combined Orifice Valve on the Attainable Mean Droplet Diameter during High-Pressure Homogenization

Cited by 2 publications

References 0 publications

Nanosuspensions in drug delivery

Nanosuspensions in drug delivery

Vitamin E Nanoparticle for Beverage Applications

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