On the influence of mechanical conditions in osteochondral defect healing

Implantation of a Polycaprolactone Scaffold with Subchondral Bone Anchoring Ameliorates Nodules Formation and Other Tissue Alterations

“…The disadvantages of this technique are low donor site availability and the size-limits of the defect. (11) (12) Tissue Engineering is an interdisciplinary science aiming at restoring damaged tissue or organs with 3-dimensional scaffolds, growth factors and/or cells. (13) (14) The scaffold must sustain initial mechanical load in the tissue and protect cells from excessive forces, i.e.…”

Application of mechanoregulatory models to simulate peri-implant tissue formation in an in vivo bone chamber

“…Although it is a well-established fact that mechanical factors modulate bone regeneration (Perren, 1979;Goodship and Kenwright, 1985;Kenwright et al, 1991;Duda et al, 2005), the mechanisms behind this modulation remain to be unraveled. Mathematical models can assist in this process by proposing certain (falsifiable) mechanisms that, after corroboration by comparison with experimental results, further the knowledge on mechanoregulated bone regeneration.…”

Effect of Implantation Accuracy on Ankle Contact Mechanics with a Metallic Focal Resurfacing Implant

“…The central bearing surface of the knee is arguably a forgiving site for implantation because of both the thickness of its cartilage and the regularity of its articular surface topography. Contact stress aberrations associated with articular defects have been studied with finite element analysis, although almost exclusively in the knee [26][27][28] . The focus of these studies was primarily on the healing of defects left untreated or treated with biological resurfacing.…”