On the interaction of azithromycin monohydrate with metallic containers

Abstract

The monohydrate form of azithromycin (an antibiotic semisynthetic derivative of erythromycin A) is difficult to manipulate due to its great propensity to stick to metallic surfaces (during crystallization, drying, grinding, etc.). In this paper, this behaviour is explained on the basis of the conformation and packing of the azithromycin molecules in this crystal form. In particular, the crystal habit favours interaction between the N and O atoms with the metal through one particular crystal face. research papers J. Appl. Cryst. (2006). 39, 826-830 J. Montejo-Bernardo et al. Azithromycin monohydrate 827

Agglomeration Mechanism of Azithromycin Dihydrate in Acetone–Water Mixtures and Optimization of the Powder Properties

“…The solid form of azithromycin depends on the solvent used in the crystallization process. 5 When the antibiotic is crystallized in a water−acetone mixture, the product obtained is the dihydrate. If the antibiotic is crystallized in a water−alcohol mixture the azithromycin form obtained is the monohydrate.…”

“…The solid form of azithromycin depends on the solvent used in the crystallization process . When the antibiotic is crystallized in a water–acetone mixture, the product obtained is the dihydrate.…”