On the issue of peptide recognition in T cell development

Crites, Travis J.; Varma, Rajat

doi:10.4161/self.1.1.10962

Cited by 3 publications

(3 citation statements)

References 70 publications

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“…It has, however, not yet been accepted that peptide-devoid MHC molecules might play a crucial role in positive selection, as suggested by us, although the situation is slowly changing ( [Hogquist and Xing, 2010] and [Crites and Varma, 2010]). The scenario which we envisage for positive selection ( [Rehm et al, 2000] and [Ziegler et al, 2009a]) involves the following steps: (i) the thymoproteasome produces predominantly peptides with a basic C-terminal residue, (ii) these peptides are transported into the endoplasmic reticulum, where they are loaded into the binding grooves of MHC class I molecules.…”

Section: T Cell Selection Within the Thymic Cortexmentioning

confidence: 94%

HLA class I-associated diseases with a suspected autoimmune etiology: HLA-B27 subtypes as a model system

Uchańska-Ziegler¹,

Loll²,

Fabian³

et al. 2012

European Journal of Cell Biology

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Section: T Cell Selection Within the Thymic Cortexmentioning

confidence: 94%

HLA class I-associated diseases with a suspected autoimmune etiology: HLA-B27 subtypes as a model system

Uchańska-Ziegler¹,

Loll²,

Fabian³

et al. 2012

European Journal of Cell Biology

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“…40,143 In both cases, those receptors that do not interact beyond a certain affinity threshold with self-molecules that are provided in the context of a selection process 'survive', and they offer the cells on which they reside, the opportunity to interact with nonself-molecules (MHC-presented 'foreign' peptides in case of T cells, ligands within the female's reproductive tract in case of spermatozoa). Therefore, comparable to the interaction of MHC-derived peptides with OR within the MOE or chemoreceptors within the VNO, 135,146,151 such nonself-reactive OR would indirectly indicate the polymorphic 'self' of the male and thereby provide the basic prerequisites for participating in Self/Nonself discrimination.…”

Section: Cryptic Female Choice Before Fertilizationmentioning

confidence: 99%

“…[31][32][33][34][35][36] Therefore, apart from its well-established, crucial role in innate and adaptive immunity, [37][38][39] the MHC appears also important in mate choice in the vast majority of vertebrates which have to date been investigated regarding this aspect. The exceptional degree of polymorphism exhibited by several MHC loci is thus not only advantageous in Self/ Nonself recognition processes during T cell development 40 and presentation of foreign antigens by MHC molecules to receptors on effector cells, [41][42][43] but also in reproduction, where a number of barriers help in securing the creation of genetically and immunologically optimal offspring. REVIEW the suggestion to designate the xMHC an 'immuno-olfactory supercomplex'.…”

Section: Introductionmentioning

confidence: 99%

Self/nonself perception, reproduction, and the extended MHC

et al. 2010

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Self/nonself perception governs mate selection in most eukaryotic species. It relies on a number of natural barriers that act before, during and after copulation. These hurdles prevent a costly investment into an embryo with potentially suboptimal genetic and immunological properties and aim at discouraging fertilization when male and female gametes exhibit extensive sharing of alleles. Due to the fact that several genes belonging to the extended major histocompatibility complex (xMHC) carry out crucial immune functions and are the most polymorphic within vertebrate genomes, it is likely that securing heterozygosity and the selection of rare alleles within this gene complex contributes to endowing the offspring with an advantage in fighting infections. Apart from MHC class I and II antigens, the products of several other genes within the xMHC are candidates for participating in mate choice, especially since the respective loci are subject to long-range linkage disequilibrium which may aid to preserve functionally connected alleles within a given haplotype. Among these loci are polymorphic odorant receptor genes that are expressed not only in the olfactory epithelium, but also within male reproductive tissues. They may thus not only be of importance in olfaction-influenced mate choice, by recognizing MHC-dependent individual-specific olfactory signals, but could also guide spermatozoa along chemical gradients to their target, the oocyte. By focusing on the human HLA complex and genes within its vicinity, we show here that the products of several xMHC-specified molecules might be involved in self/nonself perception during reproduction. Although the molecular details are often unknown, the existence of highly diverse, yet intertwined pre- and post-copulatory barriers suggests that xMHC-encoded proteins may be important for various stages of mate choice, germ cell development, as well as embryonic and foetal life in mammals and other vertebrates. Many of these genes should thus be regarded as crucial not only within the immune system, but also in reproduction.

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Kinetic proofreading and the search for nonself-peptides

Jansson¹

2011

Self/Nonself

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On the issue of peptide recognition in T cell development

Cited by 3 publications

References 70 publications

HLA class I-associated diseases with a suspected autoimmune etiology: HLA-B27 subtypes as a model system

HLA class I-associated diseases with a suspected autoimmune etiology: HLA-B27 subtypes as a model system

Self/nonself perception, reproduction, and the extended MHC

Kinetic proofreading and the search for nonself-peptides

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