On the Issue of Standardization of Symbiotics

Abstract

A multicomponent probiotic is an effective remedy for correction the disbioticheskikh of conditions of the person and is applied in complex therapy of various diseases. When developing simbiotik it is necessary to pay attention both compatibility of the used bacterial cultures, and to ensuring necessary level of standardization of these medicines. Application of the control methods allowing to define differentially quantity of viable cages of each strain in a medicine dose is the necessary instrument of standardization of simbiotik. Realization of such approach is shown on the example of the medicine "Bifilakt-BILS" containing lakto-and bifidobacteria which separate calculation is caused by use the mezhshtammovykh of distinctions of cultural properties, including activity of souring of milk, an antibiotikochuvstvitelnost, aerobic conditions. The developed control technique for this medicine is an alternative of expensive option on the basis of polymerase chain reaction.