Application of probiotics at antibiotic treatment is the effective therapeutic reception reducing negative consequences for a macroorganism microbiota in general. At such universal approach it is necessary to take the factors defining the beginning of reception of probiotics into account: to, in time or after the termination of a rate of antibacterial medicines. At purpose of simultaneous application it is advisable to consider impact of the recommended antibiotic on cellular pro-biotic medicines and to give preference less sensitive. At a comparative research by means of disco - a diffusive method of sensitivity mono - and multicomponent pro-biotic medicines to various antibiotics the essential differences allowing to range priority of their application with the appointed antibacterial medicines are revealed. Development of recommendations about combined use anti-and probiotics for optimization of courses of antibacterial therapy and increase in efficiency of complex therapy of various diseases has to be a consequence of such researches.

A multicomponent probiotic is an effective remedy for correction the disbioticheskikh of conditions of the person and is applied in complex therapy of various diseases. When developing simbiotik it is necessary to pay attention both compatibility of the used bacterial cultures, and to ensuring necessary level of standardization of these medicines. Application of the control methods allowing to define differentially quantity of viable cages of each strain in a medicine dose is the necessary instrument of standardization of simbiotik. Realization of such approach is shown on the example of the medicine "Bifilakt-BILS" containing lakto-and bifidobacteria which separate calculation is caused by use the mezhshtammovykh of distinctions of cultural properties, including activity of souring of milk, an antibiotikochuvstvitelnost, aerobic conditions. The developed control technique for this medicine is an alternative of expensive option on the basis of polymerase chain reaction.

Acid receiving treats indicators of specific activity of probiotics on a basis lakto-and bifidobacteria. The carbonic acids produced by them play an essential role in formation and functioning of an intestinal microbiota of a macroorganism. Acid receiving is the cultural property characterizing biochemical and substantially defining antagonistic activity of cages of production strains. The ability of bacteria to form and emit organic acids to the external environment affects their sensitivity to hydrochloric acid. It is established that more expressed activity of a kislotoobrazovaniye increases resistance of pro-biotic culture to bactericidal effect of gastric juice. Level of stability defines technological approaches to ensuring protection of cellular probiotics, including specifics of dosage forms.

In recent years increase in production of complex medicines on the basis of the medicinal vegetable raw materials enriched or fermented by the bacterial cul-tures playing an essential role in functioning of a mi-crobiota and, respectively, maintenance of human health is noted. Such medicines are capable to nor-malize effectively the physiological status of a macro-organism that is very important for athletes who need restoration after intensive physical activities. Successful experience of use of water extraction of oats of recovery process, sowing as means, confirms expediency of creation and application of joint com-positions with pro-biotic cultures. The research in vitro of influence of this vegetable substance on cul-tural properties of production strains lakto-and the bifidobacteria allocated from the person allows to estimate qualitatively and quantitatively prebiotic effect of oats sowing and compatibility of potential components of the complex medicines possessing adaptogens and pro-biotic action.