On the mechanical properties of bovine serum albumin (BSA) adhesives

Abstract

Biological adhesives, natural and synthetic, are of current active interest. These adhesives offer significant advantages over traditional sealant techniques, in particular, they are easier to use, and can play an integral part in the healing mechanism of tissue. Thus, biological adhesives can play a major role in medical applications if they possess adequate mechanical behavior and stability over time. In this work, we report on the method of preparation of bovine serum albumin (BSA) into a biological adhesive. We present quantitative measurements that show the effect of BSA concentration and cross-linker content on the bonding strength of BSA adhesive to wood. A comparison is then made with synthetic poly(glycidyl methacrylate) (PGMA) adhesive, and a commercial cyanoacrylate glue, which was used as a control adhesive. In addition, BSA samples were prepared and characterized for their water content, tensile strength, and elasticity. We show that on dry surface, BSA adhesive exhibits a high bonding strength that is comparable with non-biological commercial cyanoacrylate glues, and synthetic PGMA adhesive. Tensile testing on wet wood showed a slight increase in the bonding strength of BSA adhesive, a considerable decrease in the bonding strength of cyanoacrylate glue, and negligible adhesion of PGMA. Tests performed on BSA samples demonstrate that initial BSA concentration and final water content have a significant effect on the stress-strain behavior of the samples.

Degradable Adhesives for Surgery and Tissue Engineering

“…However, the mechanism of adhesion was not clearly explained. The bonding strengths on wood samples are not translational to clinical or biological adhesion, making it difficult to infer performance in physiologically relevant models …”

Enhanced angiogenesis of growth factor-free porous biodegradable adhesive made with hexanoyl group-modified gelatin

“…Gecko feet [4] have been reported to adhere to tissue/ organ surfaces with fibrous structures exhibiting strong bonding ability on solid substrates. Naturally derived polymers including gelatin [5], alginate [6], and albumin [7,8] have been employed as basic components of tissue adhesive materials.…”

In Situ BSA (Bovine Serum Albumin) Assisted Electroless Plating Method with Superior Adhesion Property

“…[30] Even in the electroless plating process, studies have been conducted to use this material as an interfacial layer that increases adhesion such as polydopamine. [31] Berchane et al directly verified that adhesion is increased by bonding to cellulose using BSA in terms of mechanical properties, [8] and Liu et al produced protein conjugated graphene oxide and reduced graphene oxide using BSA. [27] This is a technology that enables protein-based one-step reduction/decoration, and is a base technology that can produce adhesive nanosheets.…”

“…

Usually, when applying a metal layer on a hard substrate, an adhesion layer is sometimes used, [8] but if it is applied directly to a flexible substrate, cracks are formed, and constant electrical characteristics cannot be maintained. [9] In addition, since vacuum deposition such as CVD and sputter has the disadvantage that the polymer surface is damaged [10,11] and it is difficult to make a large area, it is essential to secure specialized technology when constructing a conducting layer/electronic circuit on a flexible substrate.To this end, a technology of forming a conductive layer using a solution-based electroless plating technology is an important technology for the manufacture of wearable devices/electronic skin, and many studies have been recently conducted.

…”