On the Mechanism of Action of Oral Contraceptives. I. Effect of Lynestrenol on Ovum Implantation and Oviductal Morphology in the Rat

Castro-Vázquez, Alfredo; Macome, J. C.; Carli, D. N. De; Rosner, Jorge M.

doi:10.1016/s0015-0282(16)38584-3

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Other recent electron microscopic observations of human oviductal epithelium report that con traceptive steroidal treatment enhances the estrogenizing effect on tubal tissue with increased metabolic rate in the infundibulum and synthetic (secretory) activity in the ampulla [22,66], In rats given low doses of the contraceptive steroid lynestrenol (17u-ethynil-A4-estrene-17/I-ol) from days 2 to 5 of pregnancy, histological examination of reproductive tissues on day 7 showed only the oviducts being affected, with the ampullar epithe-Hum exhibiting estrogen-influenced activity. Concurrently, the lynestrenol treatment (1 mg/day) totally prevented embryo implantation [12].…”

Section: Oviduct Fluid: Availability and Analysismentioning

confidence: 95%

Biochemistry and Physiology of Oviductal Secretions

Stone¹,

Hamner²

1975

Gynecol Obstet Invest

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The tubal environment holds a strategic location with respect to the reproductive processes. Histological visualization and biochemical analysis have shown that both oviductal tissue activity and fluid constituents are influenced by the hormonal state of the female. Also, tubal epithelial synthetic activity appears to be affected by the proximal embryo. The functional importance of differential oviductal secretions is presently unclear. However, the techniques of in vitro fertilization, embryo transfer, and culture aid in defining minimal developmental requirements and effects of cyclic secretions on embryologic events.

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Section: Oviduct Fluid: Availability and Analysismentioning

confidence: 95%

Biochemistry and Physiology of Oviductal Secretions

Stone¹,

Hamner²

1975

Gynecol Obstet Invest

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“…Lynestrenol (1), used as an oral contraceptive (Van den Driessche, Le Bars, & Chamban, 1980), shares various activities with the natural hormone progesterone. It has a strong progestational influence on the endometrium, as well as suppressing ovulation and menstruation (Castro-Vazquez, Macome, De Carli, & Rosner, 1971). In a continuation of our work on bioactive-steroids and progestagen-type compounds (Atta-ur-Rahman, Choudhary, Asif, Farooq, & Yaquoob, 1998a;Atta-urRahman, Choudhary, Asif, Farooq, & Yaqoob, 2000;Atta-ur-Rahman et al, 1998b;Choudhary, Azizuddin, & Atta-ur-Rahman, 2002;Choudhary, Musharraf, Ali, Atif, & Atta-ur-Rahman, 2004;Choudhary, Musharraf, Shaheen, & Atta-ur-Rahman, 2002;Choudhary, Shah, Musharraf, Shaheen, & Atta-ur-Rahman, 2003a;Choudhary et al, 2003b) we now report that the transformation of lynestrenol (1) by Cunninghamella elegans resulted in the formation of compounds 2, 3, and 4.…”

Section: Introductionmentioning

confidence: 99%

Oxidation of lynestrenol by the fungusCunninghamella elegans

Choudhary¹,

Atif²,

ur-Rahman³

2010

Natural Product Research

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Transformation of lynestrenol (19-nor-17alpha-pregn-4-en-20-yn-17beta-ol) (1) was carried out by incubation with Cunninghamella elegans to obtain 19-nor-17alpha-pregn-4-en-20-yn-3-one-10beta,17beta-diol (2), 19-nor-17alpha-pregn-4-en-20-yn-3-one-6beta,17beta-diol (3), and 19-nor-17alpha-pregn-4-en-20-yn-3beta,6beta,17beta-triol (4). Metabolite 4 was identified as a new compound. These metabolites were structurally characterised on the basis of spectroscopic techniques.

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Morphologic alterations in the epithelium of the human oviduct induced by a low dosis gestagen

Spornitz¹,

Ludwig

Mall-Haefeli³

1977

Arch. Gynak.

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Morphological alterations in the epithelium of the human oviduct related to continuous administration of low dosage lynestrenol were studied in 10 women by electron microscopy. The effect of lynestrenol on the morphology of the tubal epithelium was shown to be time dependent. First the discharge of secretory products from the non-ciliated cells was inhibited. Secondary to this the synthetic activities of the cells were drastically decreased. This inactivation of the tubal epithelium reached its maximum after 6 months. At this time the epithelial cells, particularly the non-ciliated cells were almost devoid of organelles and had an electron transparent cytoplasm. In addition to the action of lynestrenol on the secretory and synthetic activities of the cells a strong ciliogenetic effect could be observed after about 3 months of lynestrenol administration. The ratio of ciliated to non-ciliated cells changed from 1:1 at the beginning of the treatment to 2.9:1 after 6 months. This ratio was then maintained and could still be found in patients who had used lynestrenol for 25 and 39 months. In contrast to the persistent effect of lynestrenol on the ciliary apparatus of the cells the synthetic activities and the secretory mechanism were partially restored with long standing use. The importance of the observed changes and their possible participation in the contraceptive action of lynestrenol are discussed.

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On the Mechanism of Action of Oral Contraceptives. I. Effect of Lynestrenol on Ovum Implantation and Oviductal Morphology in the Rat

Cited by 5 publications

References 6 publications

Biochemistry and Physiology of Oviductal Secretions

Biochemistry and Physiology of Oviductal Secretions

Oxidation of lynestrenol by the fungusCunninghamella elegans

Morphologic alterations in the epithelium of the human oviduct induced by a low dosis gestagen

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