Oxidation of lynestrenol by the fungusCunninghamella elegans

Abstract

Transformation of lynestrenol (19-nor-17alpha-pregn-4-en-20-yn-17beta-ol) (1) was carried out by incubation with Cunninghamella elegans to obtain 19-nor-17alpha-pregn-4-en-20-yn-3-one-10beta,17beta-diol (2), 19-nor-17alpha-pregn-4-en-20-yn-3-one-6beta,17beta-diol (3), and 19-nor-17alpha-pregn-4-en-20-yn-3beta,6beta,17beta-triol (4). Metabolite 4 was identified as a new compound. These metabolites were structurally characterised on the basis of spectroscopic techniques.

Corydaline Inhibits Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

“…Wang, have long been used as an herbal drug for their analgesic and anti-ulcer effects [ 1 , 2 , 3 ]. Corydaline, 2,3,9,10-tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline ( Figure 1 ), is isolated from Corydalis tubers and has been demonstrated to show antiacetylcholinesterase [ 4 , 5 , 6 ] and antibutylcholinesterase activity [ 4 ], antiallergic activity [ 7 ], and antinociceptive activity [ 8 ]. Corydaline also promotes gastric emptying and facilitates gastric accommodation [ 9 ].…”