On the mechanism of the amphetamine induced vasodilatation at the rat's cerebral cortex

Rovere, A. A.; Raynald, A. C.; Scremin, Oscar U.

doi:10.1007/bf01918808

Cited by 7 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Amphetamine induces an increase in cortical blood flow without a proportional increase in cerebral metabolism (Carlsson et al, 1975). This phenomenon is blocked by atropine (Rovere et al, 1977). The cerebral vasodilatation observed with ketamine anesthesia, which is not accompanied by changes in cerebral oxygen consumption, is blocked by scopolamine and potentiated by physostigmine (Reicher et al, 1987;Oren et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

Role of nucleus basalis in cholinergic control of cortical blood flow

Scremin

Torres

Scremin

et al. 1991

J of Neuroscience Research

Self Cite

View full text Add to dashboard Cite

The present investigation was designed to determine the effect of lesions localized to the nucleus basalis/substantia innominata (NB) on resting and cholinergically activated regional cerebral cortical blood flow (rCBF). Ibotenic acid (10 micrograms) was infused locally at 1 mm caudal to bregma, 3 mm lateral to the midline, and 8 mm below the cortical surface. Effectiveness of lesions was demonstrated by histological verification of lesion sites and determination of choline acetyltransferase activity in cerebral cortex homogenates. rCBF was measured with the autoradiographic iodo-14C-antipyrine technique. Resting rCBF was similar in the hemisphere that received the NB lesion and in the contralateral (intact) side in all regions examined. Physostigmine intravenous infusion (3.3 micrograms.kg-1.min-1) enhanced rCBF in frontal, parietal, occipital, and temporal cortex. The increase was symmetrical, however, indicating inability of NB lesion to affect this phenomenon. It is concluded that the cortical cholinergic afferents originating in the NB are not involved in the control of rCBF.

show abstract