On the mode of action of the fungicide etridiazole

Radzuhn, Brigitte; Lyr, H.

doi:10.1016/0048-3575(84)90004-x

Cited by 19 publications

(8 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cell membranes of treated fungi become sensitive to solar radiation, which then destroys the structure of linoleic acid, a common membrane lipid. Another active AH fungicide ingredient, etridiazole (5-ethoxy-3(trichloromethyl)-1,2,4-thiadiazole), causes the hydrolysis of cell membrane phospholipids into free fatty acids and lysophosphatides [11], leading to the lysis of membranes, in fungi. Previous research proved that these fungicides have side effects on other soil microorganisms.…”

Section: Effects On the Synthesis Of Lipids Sterol And Othermentioning

confidence: 99%

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

et al. 2011

View full text Add to dashboard Cite

Fungicides have been used widely in order to control fungal diseases and increase crop production. However, the effects of fungicides on microorganisms other than fungi remain unclear. The modes of action of fungicides were never well classified and presented, making difficult to estimate their possible nontarget effects. In this paper, the action modes and effects of fungicides targeting cell membrane components, protein synthesis, signal transduction, respiration, cell mitosis, and nucleic acid synthesis were classified, and their effects on nontarget microorganisms were reviewed. Modes of action and potential non-target effects on soil microorganisms should be considered in the selection of fungicide in order to protect the biological functions of soil and optimize the benefits derived from fungicide use in agricultural systems.

show abstract

Section: Effects On the Synthesis Of Lipids Sterol And Othermentioning

confidence: 99%

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Mechanistically, Etridiazole inhibits fungal growth by hydrolysis of phospholipid membrane of fungal mitochondria via increased phospholipase A activity 32 . The effect of Etridiazole on mammalian cells is not well characterized, but there is evidence that it causes hemolysis and lipid peroxidation of human erythrocyte cell membranes by free radicals 32 . Thus, the biological mechanisms underlying the associations of Etridiazole with semen parameters should be investigated in future studies.…”

Section: Discussionmentioning

confidence: 99%

“…Etridiazole is classi ed as a probable human carcinogen, in part due to evidence of testes tumor and testicular interstitial cell hyperplasia in rats 26 , which suggests potential reproductive toxicity. Mechanistically, Etridiazole inhibits fungal growth by hydrolysis of phospholipid membrane of fungal mitochondria via increased phospholipase A activity 32 . The effect of Etridiazole on mammalian cells is not well characterized, but there is evidence that it causes hemolysis and lipid peroxidation of human erythrocyte cell membranes by free radicals 32 .…”

Section: Discussionmentioning

confidence: 99%

Exposome Profiling of Environmental Pollutants in Seminal Plasma and Novel Associations with Semen Parameters.

Wu,

Kalia,

Manz

et al. 2023

Preprint

View full text Add to dashboard Cite

There is evidence that indicators of male fertility are in decline globally, but the underlying causes to this pressing global concern have yet to be elucidated. While environmental chemicals are likely major contributors, current knowledge of environmental determinants of male fertility is limited and does not adequately explain this phenomenon. Previous studies have typically examined only limited sets of exposures in blood or urine, which may not accurately capture chemical burden in relevant reproductive tissues, and have overlooked a large range of potential concurrent exposures. Here, using an expansive non-targeted analysis to profile the exposome, we detected widespread environmental pollutant exposure from common and rare environmental exposures in seminal plasma. Machine learning pattern recognition and mixture models identified Etridiazole and N-nitrosodiethylamine to be negatively associated with semen parameters. Our findings suggest that these chemicals are detrimental to sperm and exposomic studies can be used to identify potential reproductive toxicants.

show abstract

“…The next generation fungicides that affect the production pathway of ERG are De Methylation Inhibitors (DMI) that prevent the demethylase production which is essential for biosynthesis of ERG and suppress pathogen finally [34,[37][38][39][40]. Dicloran and etridiazole are AH fungicides and the mechanism of action involves the cell membrane"s lysis through the deterioration of linoleic acid in the membrane and by hydrolysis of phospholipids [41]. Despite that, some fungicides affect the plasma membrane but other fungicides like acriflavine serve as an inhibitor of intracellular membrane i.e.…”

Section: Cell Membrane Componentsmentioning

confidence: 99%

Powdery Mildew A Disease of Grapes And The Fungicides Mode of Action: A Review

et al. 2022

View full text Add to dashboard Cite

Powdery mildew caused by Uncinula necator (Schw.) Burr. is one of the widespread fungal diseases of grapes that have caused economic losses through poor fruit set and low yield substantially. To decrease the inoculum potential, a disease management program must be undertaken early in the season which is imperative to reduce late-season disease problems. Because, without early control of the infection of powdery mildew, often lead to severe problem in the late season. Elemental sulfur was the foremost antifungal utilized for the control of powdery mildew which is still in use as an effective and cheap fungicide for vineyards. Sterolbiosynthesis inhibitors (SI), also called SI fungicides, are the latest products to control powdery mildew effectively. For efficient use of fungicides with no or less resistance to the pathogen, it is appropriate to spray fungicides having different mechanisms of action which are specific in function, and for more efficacy, use a mixture of such fungicides that have no harmful impact on plant growth and environment. So, for effective control of powdery mildew, a protective spray of fungicide before bloom and a subsequent spray of systemic fungicides at the time of berry formation ensure healthy and higher grapes yield. This paper reviewed the powdery mildew infection in grapevines and its effect on yield losses with details of fungicides’ mechanism of action and newly developed fungicides having broad spectrum activities.

show abstract

On the mode of action of the fungicide etridiazole

Cited by 19 publications

References 13 publications

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

Exposome Profiling of Environmental Pollutants in Seminal Plasma and Novel Associations with Semen Parameters.

Powdery Mildew A Disease of Grapes And The Fungicides Mode of Action: A Review

Contact Info

Product

Resources

About