On the Optimization of a Centrifugal Maglev Blood Pump Through Design Variations

Wu, Peng; Huo, Jia‐Dong; Dai, Weifeng; Wu, Wei‐Tao; Yin, Chengke; Shu, Li

doi:10.3389/fphys.2021.699891

Cited by 36 publications

(53 citation statements)

References 33 publications

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Computational fluid dynamics (CFD) has been increasingly used to evaluate the hemolytic and hydraulic performance of blood pumps, and assist the development and optimization of blood pumps. [1][2][3][4] Moreover, computational models may also be used for evaluations of blood pumps that are not possible experimentally or clinically. Nonetheless, CFD still suffers from uncertainties and errors when applied to blood pumps and blood circulating devices.

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confidence: 99%

The influence of non‐conformal grid interfaces on the results of large eddy simulation of centrifugal blood pumps

Huo

Zhang

et al. 2022

Artificial Organs

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Background Computational fluid dynamics has been widely used to assist the design and evaluation of blood pumps. Discretization errors associated with computational grid may influence the credibility of numerical simulations. Non‐conformal grid interfaces commonly exist in rotary machines, including rotary blood pumps. Should grid size across the interface differ greatly, large errors may occur. Methods This study explored the effects of non‐conformal grid interface on the prediction of the flow field and hemolysis in blood pumps using large eddy simulation (LES). Two benchmarks, a nozzle model and a centrifugal blood pump were chosen as test cases. Results This study found that non‐conformal grid interfaces with considerable change of grid sizes led to discontinuities of flow variables and brought errors to metrics such as pressure head (7%) and hemolysis (up to 14%). Conclusions The results on the full unstructured grid are more accurate with negligible changes of flow variables across the non‐conformal grid interface. A full unstructured grid should be employed for centrifugal blood pumps to minimize the influence of non‐conformal grid interfaces for LES simulations.

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confidence: 99%

The influence of non‐conformal grid interfaces on the results of large eddy simulation of centrifugal blood pumps

Huo

Zhang

et al. 2022

Artificial Organs

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“…The baseline design was based on a maglev blood pump previously developed in our group ( Wu et al, 2021 ). The exploded view of the pump head is shown in Figure 1A .…”

Section: Methodsmentioning

confidence: 99%

“…The total blade number was eight, with four splitter blades. The baseline pump was designed using the speed coefficient method combined with the one-dimensional design theory ( Wu et al, 2021 ). The design point was: 3,500 r/min, pressure head of 360 mmHg, and flow rate at 5 L/min.…”

Section: Methodsmentioning

confidence: 99%

“…The computational setup of the baseline blood pump is the same as those of the portable pump. The same computational setup has been employed in our previous study and verified through hydraulic experiments ( Wu et al, 2021 ). For grid sensitivity analysis, the rotational speed was set as 3,500 rpm, and inlet flow rate was set as 5 L/min for the portable pump.…”

Section: Methodsmentioning

confidence: 99%

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The Design and Evaluation of a Portable Extracorporeal Centrifugal Blood Pump

Xiang

Yin

et al. 2021

Front. Physiol.

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In recent years, blood pumps have become the bridge to heart transplantation for patients with heart failure. Portability and wearability of blood pumps should be considered to ensure patient satisfaction in everyday life. To date, the focus has been on the development of portable and wearable peripheral components, little attention has been paid to the portable and wearable performance of the blood pump itself. This study reported a novel design of a wearable and portable extracorporeal centrifugal blood pump. Based on an in-house centrifugal maglev blood pump, the wearable and portable blood pump was designed with parallel inlet and outlet pipes to improve the wearable performance. A ring cavity was set at the inlet to convert the circumferential velocity of the inlet pipe to an axial velocity. The hydraulic and hemolytic performance of the baseline and portable blood pumps were analyzed and compared. Compared with the baseline pump, the hydrodynamic and hemolytic performance of the portable pump has been maintained without serious degradation. The results of this study will improve the life quality of patients with heart failure, and enhance the clinical benefits of artificial heart.

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“…Hemodynamics play an important role in the initiation, formation, and aggregation of thrombosis ( Jama et al, 2011 ; Skorczewski et al, 2013 ; Liang et al, 2015 ). In recent years, computational fluid dynamics (CFD) studies have been employed to study hemodynamics ( Wu et al, 2020 , 2021 , 2022 ; Huo et al, 2021 ) and evaluate risk of thrombosis in abdominal aortic aneurysm, atrial appendages, aortic dissection, etc. ( Georgakarakos et al, 2009 ; Menichini et al, 2017 ; Bosi et al, 2018 ; García-Isla., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

A Hemodynamic Analysis of the Thrombosis Within Occluded Coronary Arterial Fistulas With Terminal Aneurysms Using a Blood Stasis Model

et al. 2022

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Objective: The aim of this study is to numerically evaluate thrombosis risk within occluded coronary arterial fistulas (CAF) with terminal aneurysms, and provide guidance in choosing occlusion positions, with clinical observations as reference.Method: Four patients with CAF were studied, with different occlusion positions in actual treatments. Hemodynamics simulations were conducted, with blood residue predicted using the blood stasis model. Three types of models (untreated model, aneurysm-reserved model and aneurysm-removed model) were studeid for each patient. Four metrics, i.e., proportion of high oscillatory shear index (OSI), area of high OSI, old blood volume fraction (OBVF)) and old blood volume (OBV) was obtained to distinguish the thrombosis risk of different treatments (proximal or distal occlusion), comparing with the follow-up CTA.Results: For all the postopertive models, the high OBVF, high OSI(>0.3) and low time-averaged wall shear stress (TAWSS) regions were mainly at the distal fistula, indicating these regions were prone to thrombosis. The regions where blood residue remains are roughly regions of high OSI, corresponding well with clinical observations. In contrast, TAWSS failed to distinguish the difference in thrombosis risk. Absolute values (area of high OSI, OBV) can better reflect the degree of thrombosis risk between treatment types compared with percentage values (proportion of high OSI, OBVF). By comparing with the actual clinical treatments and observations, the OBV is superior to the area of high OSI in determining treatment type.Conclusion: The OBV, a volumetric parameter for blood stasis, can better account for the CAF thrombosis and reflect the degree of blood stasis compared with OSI or TAWSS, is a more appropriate metric for thrombosis in the fistula. Together with morphological parameters, the OBV could guide clinicians to formulate more appropriate surgical plans, which is of great significance for the preoperative evaluation and treatment prognosis of CAF patients.

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On the Optimization of a Centrifugal Maglev Blood Pump Through Design Variations

Cited by 36 publications

References 33 publications

The influence of non‐conformal grid interfaces on the results of large eddy simulation of centrifugal blood pumps

The influence of non‐conformal grid interfaces on the results of large eddy simulation of centrifugal blood pumps

The Design and Evaluation of a Portable Extracorporeal Centrifugal Blood Pump

A Hemodynamic Analysis of the Thrombosis Within Occluded Coronary Arterial Fistulas With Terminal Aneurysms Using a Blood Stasis Model

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