2022
DOI: 10.3390/nu14102174
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On the Pathogenicity of the Oral Biofilm: A Critical Review from a Biological, Evolutionary, and Nutritional Point of View

Abstract: Plaque control is one of the most recommended approaches in the prevention and therapy of caries and periodontal diseases. However, although most individuals in industrialized countries already perform daily oral hygiene, caries and periodontal diseases still are the most common diseases of mankind. This raises the question of whether plaque control is really a causative and effective approach to the prevention of these diseases. From an evolutionary, biological, and nutritional perspective, dental biofilms ha… Show more

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Cited by 18 publications
(14 citation statements)
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References 114 publications
(137 reference statements)
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“…Biofilms have been involved in many clinical infections, and accumulated evidence shows that biofilms contribute to pathogenesis, especially chronic infection 54 and oral plaque 55 . Of the pathogenic biofilms, the most well-studied systems include human oral plaque.…”
Section: Discussionmentioning
confidence: 99%
“…Biofilms have been involved in many clinical infections, and accumulated evidence shows that biofilms contribute to pathogenesis, especially chronic infection 54 and oral plaque 55 . Of the pathogenic biofilms, the most well-studied systems include human oral plaque.…”
Section: Discussionmentioning
confidence: 99%
“…Biofilms have been involved in many clinical infections, and accumulated evidence shows that biofilms contribute to pathogenesis, especially chronic infection 53 and oral plaque 54 . Of the pathogenic biofilms, the most well-studied systems include human oral plaque.…”
Section: Discussionmentioning
confidence: 99%
“…Although plaque is a natural occurrence in teeth from an evolutionary, biological, and nutritional perspective, an imbalance in the microbiome of the oral pathological biofilm can lead to the development of dental caries 59 . Acid-producing cariogenic bacteria, especially S. mutans , damage the hard tooth structures in the presence of fermentable carbohydrates 38 .…”
Section: Dental Cariesmentioning
confidence: 99%