On the photochemical reactivity of phthalonimide

Histone-DNA contacts in structure/function relationships of nucleosomes as revealed by crosslinking

“…The core particle has been subjected to intensive structural studies. Neutron scatter studies of the core particle in solution proved that DNA was coiled on the outside of the histone octamer [5]. Low resolution x-ray diffraction (2 nm) 161 and 3 neutron diffraction (1.6 nm) [7] gave structures in agreement with the neutron scatter solution structure.…”

4-[(2,5-Dimethyl-1,3-thiazol-4-yl)methyl]-4-hydroxy-2-methylisoquinoline-1,3(2H,4H)-dione

“…For general background to and applications of isoquinolinedione derivatives, see: Griesbeck et al (2003); Suau & Villatoro (1994); Zhang et al (2000Zhang et al ( , 2004. For ring conformations, see: Cremer & Pople (1975).…”

“…1,3,4(2H)-Isoquinolinetrione derivatives have been used as carbonyl containing systems to take part in the photo-induced reactions with acetylenes (Zhang et al, 2000). The reaction between 1,3,4(2H)-isoquinolinetrione and toluene gave the H-abstracted product (Suau & Villatoro, 1994). Hence the compounds containing functional groups with similar bond energy, for example, allyl or aldehyde, may give rise to photo-induced H-abstracted reaction.…”

4-[(2,4-Dimethylthiazol-5-yl)methyl]-4-hydroxy-2-methylisoquinoline-1,3(2H,4H)-dione

“…For general background to and applications of isoquinolinedione derivatives, see: Griesbeck et al (2003); Hall et al (1994); Malamas & Hohman (1994); Suau & Villatoro (1994); Zhang et al (2004). For ring conformations, see: Cremer & Pople (1975).…”

“…Data collection: APEX2 (Bruker, 2009); cell refinement: SAINT (Bruker, 2009); data reduction: SAINT; program(s) used to solve structure: SHELXTL (Sheldrick, 2008); program(s) used to refine structure: SHELXTL; molecular graphics: SHELXTL; software used to prepare material for publication: SHELXTL and PLATON (Spek, 2009 (Hall et al, 1994;Malamas & Hohman, 1994). The carbonyl group on C4 of isoquinoline-1,3,4-trione is an active site for photo-induced reactions with alkenes or other hydrogen donors to give photoaddition products such as oxetanes (Suau & Villatoro, 1994). Oxazole derivatives have been used as electron donor species in the Paternò-Büchi photocycloaddition with carbonyl groups (Griesbeck et al, 2003).…”