On the potential involvement of CD11d in co-stimulating the production of interferon-  by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3

Costantini, Claudio; Micheletti, Alessandra; Calzetti, Federica; Perbellini, Omar; Tamassia, Nicola; Albanesi, Cristina; Vermi, William; Cassatella, Marco A.

doi:10.3324/haematol.2011.044578

Cited by 17 publications

(17 citation statements)

References 21 publications

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“…Although the presence of neutrophils is not regarded as a classic feature of IC-induced lupus nephritis, they contribute to the systemic inflammatory response in lupus (49), and we previously described neutrophil extracellular traps in anti-neutrophil cytoplasmic autoantibody-induced small vessel vasculitis glomerulonephritis (50). Interestingly, there is evidence for neutrophils enhancing the survival and proinflammatory properties of slanMo (51)(52)(53).…”

Section: Discussionmentioning

confidence: 89%

Intracapillary immune complexes recruit and activate slan-expressing CD16+ monocytes in human lupus nephritis

et al. 2018

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Lupus nephritis is a major cause of morbidity in patients with systemic lupus erythematosus. Among the different types of lupus nephritis, intracapillary immune complex (IC) deposition and accumulation of monocytes are hallmarks of lupus nephritis class III and IV. The relevance of intracapillary ICs in terms of monocyte recruitment and activation, as well as the nature and function of these monocytes are not well understood. For the early focal form of lupus nephritis (class III) we demonstrate a selective accumulation of the proinflammatory population of 6-sulfo LacNAc+ (slan) monocytes (slanMo), which locally expressed TNF-α. Immobilized ICs induced a direct recruitment of slanMo from the microcirculation via interaction with Fc γ receptor IIIA (CD16). Interestingly, intravenous immunoglobulins blocked CD16 and prevented cell recruitment. Engagement of immobilized ICs by slanMo induced the production of neutrophil-attracting chemokine CXCL2 as well as TNF-α, which in a forward feedback loop stimulated endothelial cells to produce the slanMo-recruiting chemokine CX3CL1 (fractalkine). In conclusion, we observed that expression of CD16 equips slanMo with a unique capacity to orchestrate early IC-induced inflammatory responses in glomeruli and identified slanMo as a pathogenic proinflammatory cell type in lupus nephritis.

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Section: Discussionmentioning

confidence: 89%

Intracapillary immune complexes recruit and activate slan-expressing CD16+ monocytes in human lupus nephritis

et al. 2018

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“…In previous observations by other investigators α D β 2 was reported to be expressed on human peripheral blood eosinophils [30], and to be upregulated on human peripheral blood granulocytes [12] and eosinophils [30] in response to stimulation. In a recent report α D was detected on human neutrophils, NK cells, and 6-sulfo- LacNAc + dendritic cells isolated from peripheral blood and cocultured in the presence of cytokines and LPS, although basal expression was apparently not examined [21]. While expression of the protein was not determined, messenger RNA for α D was detected in human peripheral blood monocytes in an earlier report [23].…”

Section: Discussionmentioning

confidence: 94%

Integrin αDβ2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling

et al. 2014

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Integrin αDβ2 is the most recently identified member of the leukocyte, or β2, subfamily of integrin heterodimers. Its distribution and functions on human leukocytes have not been clearly defined and are controversial. We examined these issues and found that αDβ2 is prominently expressed by leukocytes in whole blood from healthy human subjects, including most polymorphonuclear leukocytes and monocytes. We also found that αDβ2 is displayed by leukocytes in the alveoli of uninjured and inflamed human lungs and by human monocyte-derived macrophages and dendritic cells, indicating broad myeloid expression. Using freshly-isolated human monocytes, we found that αDβ2 delivers outside-in signals to pathways that regulate cell spreading and gene expression. Screening expression analysis followed by validation of candidate transcripts demonstrated that engagement of αDβ2 induces mRNAs encoding inflammatory chemokines and cytokines and secretion of their protein products. Thus, αDβ2 is a major member of the integrin repertoire of both circulating and tissue myeloid leukocytes in humans. Its broad expression and capacity for outside-in signaling indicate that it is likely to have important functions in clinical syndromes of infection, inflammation, and tissue injury.

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“…Several studies have shown that slanDCs interact with neutrophilic granulocytes and natural killer (NK) cells and that this considerably enhances their pro-inflammatory function [20][21][22]. Both contact-dependent (CD18/ICAM-1) and cytokine-mediated (IL-12, IFN-γ) signals are involved in this positive feedback loop.…”

Section: Psoriasismentioning

confidence: 99%

The role of human 6‐sulfo LacNAc dendritic cells (slanDCs) in autoimmunity and tumor diseases

Döbel

Schäkel

2014

J Deutsche Derma Gesell

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SummaryDendritic cells play a central role in the regulation of immunological reactivity. The existence of functionally specialized populations of dendritic cells in the skin is a consequence of qualitatively different attacks on our organism. slanDCs are human inflammatory dendritic cells that are characterized by the specific expression of the carbohydrate 6-sulfo LacNAc (slan). After phenotypic maturation, slanDCs are capable of producing very high amounts of proinflammatory mediators such as IL-12, TNF-α, IL-1β and IL-23. Recent data describe a potential role of slanDCs in a number of different diseases like psoriasis, lupus erythematosus, and tumors, thus opening up new areas of research on their respective pathogenesis. Furthermore, a slanDC-specific targeting system has been developed as a basis for direct therapeutic manipulation. Future challenges of slanDC research include deepening our understanding of the significance of slanDCs in the regulation of adaptive and innate immune responses, as well as translating this knowledge into therapeutic options.

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On the potential involvement of CD11d in co-stimulating the production of interferon- by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3

Cited by 17 publications

References 21 publications

Intracapillary immune complexes recruit and activate slan-expressing CD16+ monocytes in human lupus nephritis

Intracapillary immune complexes recruit and activate slan-expressing CD16+ monocytes in human lupus nephritis

Integrin αDβ2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling

The role of human 6‐sulfo LacNAc dendritic cells (slanDCs) in autoimmunity and tumor diseases

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