On the Presence of Immunoreactive Growth Hormone in a Bronchogenic Carcinoma

Dp, Cameron; Hg, Burger; Dm, DeKretzer; Kj, Catt; Jb, Best

doi:10.1111/imj.1969.18.2.143

Cited by 22 publications

(6 citation statements)

References 6 publications

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“…Following tumour excision, the G H levels fell from 38 to 3-5 ng/ml. Immunoreactive GH was also demonstrated in an extract of a poorly differentiated adenocarcinoma of lung from a patient with HPOA (Cameron et al, 1969). However, high levels of immunoreactive GH are found in gastric tumours in the absence of HPOA , and abnormal glucose tolerance with nonsuppressible GH levels in lung cancer, or paradoxical rises in GH after glucose loading in patients with lung or endometrial carcinoma, are not correlated with HPOA (Ennis et al, 1973;Benjamin et al, 1969).…”

Section: E C T O P I C G R O W T H H O R M O N Ementioning

confidence: 94%

Ectopic Hormone Production by Non‐endocrine Tumours

Rees

Ratcliffe

1974

Clinical Endocrinology

151

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The recognition that certain clinical syndromes are due to secretion of hormones by 'non endocrine' tumours, has been among the major developments in endocrinology in the last decade and has forged a new link with oncology. The phenomenon has general clinical and biochemical implications. Clinicians now recognize that the accompanying metabolic derangements may be more malign than the neoplasm itself, may significantly affect prognosis, and they use the measurement of plasma hormone levels and related substances for diagnosis and management. From the biochemical point of view, the study of ectopic hormone secretion provides new insight into the state of tissue differentiation. It serves as an excellent model for the broader field of inappropriate tumour products, since the structure of most hormones is known and because recent technical advances have improved methods for their purification and assay. Several reviews have discussed the clinical aspects of ectopic humoral syndromes (Bower

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Section: E C T O P I C G R O W T H H O R M O N Ementioning

confidence: 94%

Ectopic Hormone Production by Non‐endocrine Tumours

Rees

Ratcliffe

1974

Clinical Endocrinology

151

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“…Evidence to support this concept is primarily anecdotal but sufficiently intriguing to warrant further examination. The production by tumors of pharmacologically active substances (77)(78)(79)(80)(81)(82)(83)(84) such as vasopressin (85)(86)(87)(88)(89) and bombesin (90,91) has been documented but whether these substances participate in the pathogenesis of metastases has not been established. Both vasopressin and bombesin are, under defined conditions, mitogenic but their role in encouraging tumor cell growth in vivo and 'conditioning' organs for metastatic colonization has not been thoroughly investigated (92)(93)(94)(95)(96).…”

Section: Organ Predispositionmentioning

confidence: 99%

Shaping future strategies for the pharmacological control of tumor cell metastases

Greig¹,

Trainer²

1986

Cancer Metast Rev

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The eradication of established metastases in patients with malignant tumors is the single most important objective in clinical oncology. The current panel of antineoplastic agents discovered through random and semiempirical screening procedures has proven largely ineffective in treating disseminated disease and there is a clear and urgent need for more efficient antimetastatic drugs. Unfortunately, although progress has been made in examining the biology of metastatic spread, our understanding of the pharmacology, biochemistry and molecular genetics of this process is meager and insufficient to provide a rational foundation for the design of mechanism-based antineoplastic agents. Faced on the one hand with the failure of existing drugs to control metastatic spread and on the other with a dearth of alternative pharmacological approaches, the prospect of offering significantly improved therapy to the cancer patient of the 1990's is poor. The challenge of the coming decade lies in obtaining better insights into the molecular mechanisms of metastasis and using this information to identify pharmacological opportunities to curtail the proliferation of secondary tumor growths. As a first step toward this goal we need to define more rigorously what constitutes a therapeutic target in malignant disease and what steps in the pathogenesis of cancer metastasis represent the gravest risk to the patient and thus are most eligible for direct pharmacological intervention. In addressing these issues and developing future strategies for antimetastatic drugs, Paget's 100 year-old 'seed and soil' hypothesis continues to offer a useful conceptual framework for analysis of metastatic behavior. Although Paget's proposal has been validated by a century of clinical observation, efforts to define the 'seed and soil' theory in molecular terms have not been attempted. With the advent of more efficient methodologies for culturing human normal and neoplastic cells coupled with the availability of microanalytical technologies it now becomes possible to investigate and identify the complementary biochemical components of the tumor cell 'seed' and organ 'soil' that combine to encourage the proliferation of metastases. With this information the design of specific pharmacological strategies to uncouple the 'seed and soil' relationship may emerge as a potential therapeutic approach for antagonizing the growth of disseminated malignant tumors.

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“…Human chorionic gonadotropin and immunoreactive growth hormone were localized in bronchogenic carcinomas with immunofluorescence (142,143). These hormones have been associated mainly with large cell carcinomas and adenocarcinomas of the lung (144).…”

Section: Markers Of Lung Tumorsmentioning

confidence: 99%

Immunohistochemical techniques and their applications in the histopathology of the respiratory system.

Linnoila¹,

Petrusz²

1984

Environ Health Perspect

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Subsequent to the first report in the 1940s on incubation of tissue sections with fluorescein-conjugated antibodies for localization of antigens, a great number of modifications were introduced to improve the validity of immunohistochemistry which has become a growingly popular tool. The use of immunoenzymatic techniques eliminates the need for expensive fluorescence microscopy equipment, the lack of permanency of preparations and the lack of electron density required in ultrastructural localization of antigens. Regardless of the technique, it is also important to choose a correct fixation which allows the proper preservation of antigens and morphology and the penetration of antibodies through the entire thickness of the preparation. A variety of immunohistochemical techniques have been applied to study several components of the lung, such as collagen, surface active material, lung specific antigens, and enzymes and the detection of tumor markers, immunoglobulins and infectious agents in the respiratory system which is reviewed. The large surface area and the multiplicity of cell types provided by the respiratory tract epithelium of humans for exposure to microbial as well as toxic substances in the environment make this organ system very vulnerable but a good early indicator of adverse health effects. Immunohistochemistry provides valuable information complementary to the immunochemical and biochemical characterization of this barrier.

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On the Presence of Immunoreactive Growth Hormone in a Bronchogenic Carcinoma

Cited by 22 publications

References 6 publications

Ectopic Hormone Production by Non‐endocrine Tumours

Ectopic Hormone Production by Non‐endocrine Tumours

Shaping future strategies for the pharmacological control of tumor cell metastases

Immunohistochemical techniques and their applications in the histopathology of the respiratory system.

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