On the Presence of "Prostatic Secretion Protein" in Different Species.

High resolution analysis of human prostatic fluid by two‐dimensional electrophoresis

“…No attempt has been made to functionally identify any of the proteins numbered on the schematic. It is possible that the groups of spots (8, 9,10,11), (12,13,14,15,16), and (17,18,19,20,21) are different charge states of three different proteins. The addition of acidic moieties to a glycopeptide would generate a series of spots with slightly increasing molecular weight in the acidic direction.…”

The Endocrinology and Developmental Biology of the Prostate*

“…More recently Matusik and co-workers (109)(110)(111) have cloned two hormonally regulated dorsolateral prostate messenger RNAs (mRNAs), one of which encodes a zinc-binding protein responsible for zinc accumulation in the lateral prostate, while the function of the other, which is also expressed in the seminal vesicle, is unknown. PBP, which is also known as prostatein (112), aprotein (113,114), prostatic secretory protein (115), or estramustine-binding protein (116), is a glycoprotein whose synthesis is almost entirely confined to the ventral prostate (107,116). It consists of two nonidentical subunits each containing a 13,000 M r glycopeptide (C3) disulfide-bonded to either an 8,000 M r (Cl) or 11,000 M r (C2) peptide (117)(118)(119).…”

Mapping of rat prostatic binding protein genes C1, C2, and C3 to rat chromosome 5 by in situ hybridization

“…This is not unexpected since rat chromosome 5 and mouse chromosome 4 share other homoeologous genes (Yoshida, 1982(Yoshida, , 1983. It would therefore be of interest to investigate whether PBP-related genes can be detected on mouse chromosome 4. the more since mouse prostate contains proteins immunochemically similar to PBP (Pousette et al, 1980), and because Parker et al (1982) reported hybridization at low as well as at high stringency with a C2-specific cDNA clone on mouse genomic DNA blots.…”