On the Proliferation Stimulating Nature of the Regenerating Nerve Fibers

The Control of Mitotic Activity in Adult Mammalian Tissues

“…These effects of nervous activity recall the fact that cell division, particularly during regeneration, may be strongly influenced by the presence or absence of nervous tissue (see Needham, 1952). Most of the evidence comes from studies of amphibians and the results, for instance of Overton ( I~~o u , b) and Inoue (1957Inoue ( , 1958, can be taken to suggest that nervous tissue is able to secrete some mitosis-stimulating factor. In mammals Kulagin (19594 b, 1960) has also noted that by cutting the nerve supply to one limb a mitotic depression can be induced in the epidermis of that limb.…”

A Theoretical Approach to the Regulatory Mechanism in the Brain-Hypophyseal-Gonadal System with Reference to its Mathematical Modeling and Computer Simulation

“…In comparison with the male, Dp of the female rat is so sensitive (Inoue, 1969) that NsL and NiL are greatly modified by PH levels. The results are then informed to the hypophysis by means of neurohormones, to cause changes in secretory patterns of gonadotropins ( Figure 5).…”

“…Figure 5 (below). Precise data on LH secretion were already obtained by Kobayashi et al (1968 (Inoue, 1969). Similarly, the pathways store mechanism may exist in the male too, exhibiting no functions in normal conditions just like those from Da in the female.…”