A Theoretical Approach to the Regulatory Mechanism in the Brain-Hypophyseal-Gonadal System with Reference to its Mathematical Modeling and Computer Simulation

Inoue, Shimpei; Nakamura, Touichi; Sekiguchi, Takashi

doi:10.1507/endocrj1954.17.567

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1979

2009

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Cited by 6 publications

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“…By this, physiologic functions are identified with hormones and their changes are identified with changes in concentration of hormones. Consequently, the whole neuroendocrine system (NES) is represented as a multiloop control system with multiple feedback couplings (Kogan et al, 1972;Rashevsky, 1966;Carson, Cramp, 1976;Inoue et al, 1970;Stear, 1975;Belikova, Lyapunov and Starovoitova, 1972). It is believed that hormones may possess different physiologic properties depending on dosage and site (Selye, 1972).…”

mentioning

confidence: 99%

Morpho-functional principle of neuroendocrine system analysis

Prochukhanov

Ravkin

1979

Acta Biotheor

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mentioning

confidence: 99%

Morpho-functional principle of neuroendocrine system analysis

Prochukhanov

Ravkin

1979

Acta Biotheor

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Computer simulation for hormones related to primary thyropathy

Hatakeyama¹,

Yagi²

1985

Biol. Cybern.

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We propose a mathematical model of the human hypothalamus-anterior pituitary-thyroid system regulating basal metabolism, and practice computer simulation concerning primary thyropathy such as Graves' disease, hypothyroidism, T4-toxicosis and T3-toxicosis by use of this model. In order to throw light on properties of the system, indicial responses of the hormones, T4, T3, rT3, and TSH, and the function of the thyroid gland are computed. Medical treatments for Graves' disease and for hypothyroidism are simulated with a view to enhancing clinical significance. Performance of the simulation leads to an interesting result that when the convertion rate of blood T4 to blood T3 increases, explicit T3-toxicosis occurs, although the function of the thyroid gland is normal.

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1990

Organisation and Regulation

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A Theoretical Approach to the Regulatory Mechanism in the Brain-Hypophyseal-Gonadal System with Reference to its Mathematical Modeling and Computer Simulation

Cited by 6 publications

References 7 publications

Morpho-functional principle of neuroendocrine system analysis

Morpho-functional principle of neuroendocrine system analysis

Computer simulation for hormones related to primary thyropathy

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